Case Report
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World J Gastroenterol. Mar 28, 2013; 19(12): 2005-2008
Published online Mar 28, 2013. doi: 10.3748/wjg.v19.i12.2005
Coexistence of gastrointestinal stromal tumor, esophageal and gastric cardia carcinomas
Yong Zhou, Xu-Dong Wu, Quan Shi, Jing Jia
Yong Zhou, Department of General Surgery, Yancheng City No.1 People’s Hospital, Yancheng 224005, Jiangsu Province, China
Xu-Dong Wu, Department of Gastroenterology, Yancheng City No.1 People’s Hospital, Yancheng 224005, Jiangsu Province, China
Quan Shi, Department of Radiology, Yancheng City No.1 People’s Hospital, Yancheng 224005, Jiangsu Province, China
Jing Jia, Department of Nephrology, Yancheng City No.1 People’s Hospital, Yancheng 224005, Jiangsu Province, China
Author contributions: Zhou Y, Wu XD, Shi Q and Jia J contributed to the manuscript writing and revision.
Correspondence to: Xu-Dong Wu, PhD, Department of Gastroenterology, Yancheng City No.1 People’s Hospital, 16 Yuehe Road, Yancheng 224005, Jiangsu Province, China. hnjsycwxd@163.com
Telephone: + 86-510-88508910 Fax: +86-510-88508910
Received: December 6, 2012
Revised: December 27, 2012
Accepted: January 11, 2013
Published online: March 28, 2013
Abstract

Gastric gastrointestinal stromal tumor (GIST), esophageal squamous cell carcinoma and gastric cardia adenocarcinoma are distinct neoplasms originating from different cell layers; therefore, simultaneous development of such carcinomas is relatively rare. Auxiliary examinations revealed coexistence of esophageal and gastric cardia carcinoma with lymph node metastasis in a 77-year-old man. Intraoperatively, an extraluminal tumor (about 6.0 cm × 5.0 cm × 6.0 cm) at the posterior wall of the gastric body, a tumor (about 2.5 cm × 2.0 cm) in the lower esophagus, and an infiltrative and stenosing tumor (about 1.0 cm × 2.0 cm) in the gastric cardia were detected. Wedge resection for extraluminal gastric tumor, radical esophagectomy for lower esophageal tumor, and cardiac resection with gastroesophageal (supra-aortic arch anastomoses) were performed. Postoperative histological examination showed synchronous occurrence of gastric GIST, esophageal squamous cell carcinoma, and gastric cardia adenocarcinoma. Furthermore, immunohistochemistry indicated strong staining for c-Kit/CD117, Dog-1, Ki-67 and smooth muscle, while expression of S-100 and CD34 was negative.

Keywords: Gastrointestinal stromal tumor, Esophageal squamous cell carcinoma, Gastric cardia adenocarcinoma