Brief Article
Copyright ©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Oct 21, 2012; 18(39): 5589-5594
Published online Oct 21, 2012. doi: 10.3748/wjg.v18.i39.5589
Photodynamic therapy prolongs metal stent patency in patients with unresectable hilar cholangiocarcinoma
Tae Yoon Lee, Young Koog Cheon, Chan Sup Shim, Young Deok Cho
Tae Yoon Lee, Young Koog Cheon, Chan Sup Shim, Digestive Disease Center, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 143-729, South Korea
Young Deok Cho, Institute for Digestive Research and Digestive Disease Center, Soonchunhyang University College of Medicine, Seoul 140-743, South Korea
Author contributions: Cheon YK and Shim CS designed the research; Cheon YK and Cho YD performed the research; Lee TY and Cheon YK analyzed the data; and Lee TY and Cheon YK wrote the paper.
Correspondence to: Young Koog Cheon, MD, PhD, Professor, Digestive Disease Center, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, 120-1 Neungdong-ro, Gwangjin-gu, Seoul 143-729, South Korea. yksky001@hanmail.net
Telephone: +82-2-20308195 Fax: +82-2-20305029
Received: June 1, 2012
Revised: August 16, 2012
Accepted: August 25, 2012
Published online: October 21, 2012
Abstract

AIM: To evaluate the effect of photodynamic therapy (PDT) on metal stent patency in patients with unresectable hilar cholangiocarcinoma (CC).

METHODS: This was a retrospective analysis of patients with hilar CC referred to our institution from December, 1999 to January, 2011. Out of 232 patients, thirty-three patients with unresectable hilar CC were treated. Eighteen patients in the PDT group were treated with uncovered metal stents after one session of PDT. Fifteen patients in the control group were treated with metal stents alone. Porfimer sodium (2 mg/kg) was administered intravenously to PDT patients. Forty-eight hours later, PDT was administered using a diffusing fiber that was advanced across the tumor by either endoscopic retrograde cholangiopancreatography or percutaneous cholangiography. After performance of PDT, uncovered metal stents were inserted to ensure adequate decompression and bile drainage. Patient survival rates and cumulative stent patency were calculated using Kaplan-Meier analysis with the log-rank test.

RESULTS: The PDT and control patients were comparable with respect to age, gender, health status, pre-treatment bilirubin, and hilar CC stage. When compared to control, the PDT group was associated with significantly prolonged stent patency (median 244 ± 66 and 177 ± 45 d, respectively, P = 0.002) and longer patient survival (median 356 ± 213 and 230 ± 73 d, respectively, P = 0.006). Early complication rates were similar between the groups (PDT group 17%, control group 13%) and all patients were treated conservatively. Stent malfunctions occurred in 14 PDT patients (78%) and 12 control patients (80%). Of these 26 patients, twenty-two were treated endoscopically and four were treated with external drainage.

CONCLUSION: Metal stenting after one session of PDT may be safe with acceptable complication rates. The PDT group was associated with a significantly longer stent patency than the control group in patients with unresectable hilar CC.

Keywords: Bile duct cancer, Palliative endoscopic stenting, Photodynamic therapy, Outcome