Case Report
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World J Gastroenterol. Aug 28, 2012; 18(32): 4450-4453
Published online Aug 28, 2012. doi: 10.3748/wjg.v18.i32.4450
Candida-associated gastric ulcer relapsing in a different position with a different appearance
Kenji Sasaki
Kenji Sasaki, Department of Internal Medicine, Tome Municipal Hospital of Toyosato, Tome, Miyagi 987-0364, Japan
Author contributions: Sasaki K solely contributed to this paper.
Correspondence to: Kenji Sasaki, MD, Department of Internal Medicine, Tome Municipal Hospital of Toyosato, 74-1 Doteshita, Toyosato, Tome, Miyagi 987-0364, Japan. kydosarnymai@aria.ocn.ne.jp
Telephone: +81-225-762023 Fax: +81-225-762923
Received: June 9, 2012
Revised: August 7, 2012
Accepted: August 14, 2012
Published online: August 28, 2012
Abstract

An 87-year-old, Japanese woman was shown to have a submucosal tumor-like lesion with a deep, central ulceration covered with thick, whitish exudate in the stomach. Biopsy showed Candida tropicalis but not Helicobacter pylori (H. pylori). She had no predisposing factors or history of peptic ulcers nor had taken non-steroidal anti-inflammatory drugs (NSAIDs), diagnosed with Candida-associated gastric ulcer. Though cured of the lesion, she developed another ulcer in a different position, in which Candida was demonstrated but H. pylori was undetectable. This is the first case of recurrent Candida-associated gastric ulcer in the world. Detected in both the original and recurrent lesions in an H. pylori-negative patient with no antecedent ulcers who had not taken NSAIDs, Candida is considered, contrary to the prevailing opinion, to play an etiologic role in ulcer formation.

Keywords: Candida-associated gastric ulcer; Gastric candidiasis; Helicobacter pylori-negative gastric ulcer; Non-steroidal anti-inflammatory drugs-induced gastric ulcer; Recurrent gastric ulcer