Original Article
Copyright ©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jun 28, 2012; 18(24): 3081-3088
Published online Jun 28, 2012. doi: 10.3748/wjg.v18.i24.3081
Pseudomyxoma peritonei of 92 Chinese patients: Clinical characteristics, pathological classification and prognostic factors
Ai-Tao Guo, Yan-Mi Li, Li-Xin Wei
Ai-Tao Guo, Li-Xin Wei, Department of Pathology, the General Hospital of the People’s Liberation Army, Beijing 100853, China
Yan-Mi Li, Department of Sonography, the General Hospital of the People’s Liberation Army, Beijing 100853, China
Author contributions: Guo AT contributed to this work; Guo AT and Wei LX designed the research; Guo AT and Li YM performed the research; Guo AT wrote the paper; and Wei LX modified the paper.
Correspondence to: Dr. Li-Xin Wei, Department of Pathology, the General Hospital of People’s Liberation Army, Beijing 100853, China. weilx301@263.net
Telephone: +86-10-66936253 Fax: +86-10-66937520
Received: December 5, 2011
Revised: April 16, 2012
Accepted: May 26, 2012
Published online: June 28, 2012

AIM: To assess the clinicopathologic features and its relationship with prognosis of pseudomyxoma peritonei (PMP) in Chinese patients.

METHODS: The clinicopathologic features and follow-up data of 92 patients with PMP were reviewed and retrospectively analyzed. The cases were categorized into three groups: disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinomatosis (PMCA), and peritoneal mucinous carcinomatosis with intermediate or discordant features (PMCA-I/D). The log-rank test was used to analyze survival for each group and various clinicopathological parameters. Multivariate Cox proportional-hazard models were constructed to determine the important factors associated with survival.

RESULTS: The median age at diagnosis was 51.9 years (range: 22-76 years). The median follow up was 124 mo. The 3-, 5- and 10-year survival rates were 74.0%, 67.4% and 49.1%, respectively. There were 49 (53.2%) patients with DPAM, 26 (28.3%) with PMCA-I and 17 (18.5%) with PMCA. Patients with DPAM, PMCA-I/D and PMCA exhibited statistically significant difference in survival (P = 0.001). The 3 year survival for DPAM, PMCAI/D and PMCA was 97.0%, 80.0% and 67.0%, respectively; the 5 year survival was 80.0%, 67.0% and 50.0%, respectively; and the 10 year survival was 65.0%, 28.0% and 14.0%, respectively. Survival rate was significantly lowest in patients < 40 age years of age (P = 0.011). Appendiceal tumor and extra-ovarian parenchymal organ involvement were significantly related to overall survival. Patients with appendiceal mucinous adenocarcinoma (MACA) showed the significantly poorer prognosis (P = 0.011). Multivariate analysis showed that pathological classification, age, appendiceal tumor were significant related to overall survival.

CONCLUSION: The clinical process “PMP” should be pathologically classified into DPAM, PMCA and PMCA-I/D. Pathological classification, age, appendiceal MACA are survival independent predictors in Chinese patients with PMP.

Keywords: Pseudomyxoma peritonei, Pathologic, Clinical, Classification, Prognosis