Brief Article
Copyright ©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jun 21, 2012; 18(23): 2995-3003
Published online Jun 21, 2012. doi: 10.3748/wjg.v18.i23.2995
Overexpression of metastasis-associated in colon cancer 1 predicts a poor outcome of hepatitis B virus-related hepatocellular carcinoma
Jian-Hui Qu, Xiu-Juan Chang, Yin-Ying Lu, Wen-Lin Bai, Yan Chen, Lin Zhou, Zhen Zeng, Chun-Ping Wang, Lin-Jing An, Li-Yan Hao, Gui-Lin Xu, Xu-Dong Gao, Min Lou, Ji-Yun Lv, Yong-Ping Yang
Jian-Hui Qu, Xiu-Juan Chang, Yin-Ying Lu, Wen-Lin Bai, Yan Chen, Lin Zhou, Zhen Zeng, Chun-Ping Wang, Lin-Jing An, Li-Yan Hao, Gui-Lin Xu, Xu-Dong Gao, Min Lou, Ji-Yun Lv, Yong-Ping Yang, Center of Therapeutic Research for Liver Cancer, The 302nd Hospital, Beijing 100039, China
Ji-Yun Lv, Yong-Ping Yang, Institute for Infectious Disease, The 302nd Hospital, Beijing 100039, China
Author contributions: Qu JH and Chang XJ contributed equally to this study; Qu JH, Chang XJ, Lv JY and Yang YP designed the research; Qu JH, Chang XJ, Lu YY, Bai WL, Chen Y, Zhou L, Zeng Z and Wang CP performed the research; Qu JH, Chang XJ, An LJ, Hao LY, Xu GL, Gao XD and Lou M analyzed the data; Qu JH and Yang YP wrote the paper.
Supported by Grants from the Key Scientific and Technological Research Foundation of the National Special-purpose Program, No. 2008ZX10002-018 and from the Capital Medical Development and Research in Beijing, China, No. 2007-1021 and 2009-2041
Correspondence to: Yong-Ping Yang, Chief, Center of Therapeutic Research for Liver Cancer, The 302nd Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China. yongpingyang@hotmail.com
Telephone: +86-10-66933429 Fax: +86-10-63879193
Received: August 4, 2011
Revised: March 22, 2012
Accepted: May 6, 2012
Published online: June 21, 2012
Abstract

AIM: To investigate the intratumoral expression of metastasis-associated in colon cancer 1 (MACC1) and c-Met and determine their clinical values associated with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).

METHODS: A retrospective study admitted three hundred fifty-four patients with HBV-related HCC. The expression and distribution of MACC1 and c-Met were assessed by quantitative real-time polymerase chain reaction and immunohistochemistry staining. Prognostic factors influencing survival, metastasis and recurrence were assessed.

RESULTS: Intratumoral MACC1 level was found to be associated with HCC disease progression. Both median tumor-free survival (TFS) and overall survival (OS) were significantly shorter in the postoperative HCC patients with high intratumoral MACC1 expression, as compared to those with low intratumoral MACC1 levels (TFS: 34 mo vs 48.0 mo, P < 0.001; OS: 40 mo vs 48 mo, P < 0.01). Multivariable analysis indicated that high MACC1 expression or co-expression with c-Met were independent predictors for HCC clinic outcome (P < 0.001).

CONCLUSION: High intratumoral MACC1 expression can be associated with enhanced tumor progression and poor outcome of HBV-related HCC. MACC1 may serve as a prognostic biomarker for postoperative HCC.

Keywords: Hepatocellular carcinoma; Metastasis-as-sociated in colon cancer 1; c-Met; Prognostic factor; Recurrence