Nardo GD, Oliva S, Aloi M, Ferrari F, Frediani S, Marcheggiano A, Cucchiara S. A pediatric non-protein losing Menetrier's disease successfully treated with octreotide long acting release. World J Gastroenterol 2012; 18(21): 2727-2729 [PMID: 22690084 DOI: 10.3748/wjg.v18.i21.2727]
Corresponding Author of This Article
Salvatore Cucchiara, MD, PhD, Department of Pediatrics, Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy. salvatore.cucchiara@uniroma1.it
Article-Type of This Article
Case Report
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World J Gastroenterol. Jun 7, 2012; 18(21): 2727-2729 Published online Jun 7, 2012. doi: 10.3748/wjg.v18.i21.2727
A pediatric non-protein losing Menetrier's disease successfully treated with octreotide long acting release
Giovanni Di Nardo, Salvatore Oliva, Marina Aloi, Federica Ferrari, Simone Frediani, Adriana Marcheggiano, Salvatore Cucchiara
Giovanni Di Nardo, Salvatore Oliva, Marina Aloi, Federica Ferrari, Simone Frediani, Adriana Marcheggiano, Salvatore Cucchiara, Department of Pediatrics, Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, 00161 Rome, Italy
Adriana Marcheggiano, Department of Medical Science, Sapienza University of Rome, 00161 Rome, Italy
Author contributions: Di Nardo G performed the second endoscopy with mucosectomy and wrote the manuscript; Oliva S performed the first endoscopy and wrote the manuscript; Aloi M and Ferarri F performed all clinical investigations and followed-up the patient; Frediani S suggested the use of the octreotide as a possible therapeutic tool; Marcheggiano A performed all the histological examinations; Cucchiara S approved the use of octreotide and strongly revised a draft of the paper.
Correspondence to: Salvatore Cucchiara, MD, PhD, Department of Pediatrics, Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy. salvatore.cucchiara@uniroma1.it
Telephone: +39-6-49979324 Fax: +39-6-49979325
Received: March 25, 2011 Revised: August 13, 2011 Accepted: March 9, 2012 Published online: June 7, 2012
Abstract
Pediatric Menetrier’s disease (MD) is an uncommon, acute, self-limited hypertrophic gastropathy characterized by enlarged gastric folds associated with epithelial hyperplasia and usually accompanied by protein losing gastropathy. Gastric cytomegalovirus infection is found in one third of MD children and its treatment is often associated with remission. Diagnosis often requires full-thickness biopsy due to inability to detect typical histological findings with conventional endoscopic biopsy. We report an uncommon case of non self-limited pediatric MD needing endoscopic mucosal resection for diagnosis which was then successfully treated with octreotide long-acting release (LAR). To the best of our knowledge, this is the first pediatric MD case successfully treated with octreotide LAR. Our experience suggests octreotide LAR as treatment for refractory MD before gastrectomy.
