Brief Article
Copyright ©2012 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jan 14, 2012; 18(2): 168-174
Published online Jan 14, 2012. doi: 10.3748/wjg.v18.i2.168
18F-fluoro-2-deoxyglucose uptake on PET CT and glucose transporter 1 expression in colorectal adenocarcinoma
Ran Hong, Sung-Chul Lim
Ran Hong, Sung-Chul Lim, Department of Pathology and Research Center for Resistant cells, Medical School, Chosun University, Gwangju 501-140, South Korea
Author contributions: Hong R and Lim SC contributed equally to this work, including research design, data analysis, and writing and editing the manuscript.
Supported by National Research Foundation of Korea Grant funded by the Ministry of Education, Science and Technology through the Research Center for Resistant Cells, No. R13-2003-009
Correspondence to: Dr. Sung-Chul Lim, Department of Pathology and Research center for Resistant cells, Medical school, Chosun University, Gwangju 501-140, South Korea.
Telephone: +82-62-2306343 Fax: +82-62-2344584
Received: April 19, 2011
Revised: June 27, 2011
Accepted: July 5, 2011
Published online: January 14, 2012

AIM: To evaluate the correlation between the level of 18F-fluoro-2-deoxyglucose (18F-FDG) uptake and glucose transporter 1 (GLUT1) expression in colorectal adenocarcinoma (CRA).

METHODS: Forty four patients with resected CRA and preoperative 18F-FDG positron emission tomography - computed tomography data were investigated in this study. Comparison of maximum standardized uptake value (SUVmax) of the lesion was made with GLUT1 expression by immunohistochemistry and various clinicopathologic factors including tumor volume, invasion depth, gross finding, and lymph node metastasis.

RESULTS: SUVmax was 14.45 ± 7.0 in negative GLUT1 expression cases, 15.51 ± 5.7 in weak GLUT1 expression cases, and 16.52 ± 6.8 in strong GLUT1 expression cases, and there was no correlation between between GLUT1 expression and SUVmax. SUVmax was significantly correlated with tumor volume (P < 0.001). However, there was no significant differences in SUVmax and GLUT1 expression among other clinicopathologic factors.

CONCLUSION: GLUT1 expression does not correlates significantly with 18F-FDG uptake in CRA. 18F-FDG uptake was increased with tumor volume, which is statistically significant.

Keywords: 18F-fluoro-2-deoxyglucose, Glucose transporter 1, Colorectal cancer