Okumura K, Ikebe M, Shimokama T, Takeshita M, Kinjo N, Sugimachi K, Higashi H. An unusual enteropathy-associated T-cell lymphoma with MYC translocation arising in a Japanese patient: A case report. World J Gastroenterol 2012; 18(19): 2434-2437 [PMID: 22654438 DOI: 10.3748/wjg.v18.i19.2434]
Corresponding Author of This Article
Kenji Okumura, MD, Department of Surgery, Nippon Steel Yawata Memorial Hospital, 1-1-1, Harunomachi, Yahatahigashi-ku, Kitakyushu 805-8508, Japan. kenjiokumura@kyudai.jp
Article-Type of This Article
Case Report
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Kenji Okumura, Masahiko Ikebe, Nao Kinjo, Keishi Sugimachi, Hidefumi Higashi, Department of Surgery, Nippon Steel Yawata Memorial Hospital, Kitakyushu 805-8508, Japan
Tatsuro Shimokama, Department of Pathology, Nippon Steel Yawata Memorial Hospital, Kitakyushu 805-8508, Japan
Morishige Takeshita, Department of Pathology, School of Medicine, Fukuoka University, Fukuoka 814-0180, Japan
Author contributions: Okumura K and Ikebe M contributed equally to this work; Okumura K, Ikebe M, Shimokama T, Takeshita M, Kinjo N, Sugimachi K and Higashi H designed the research; Okumura K, Shimokama T and Takeshita M performed the research; Shimokama T and Takeshita M contributed new reagents/analytic tools; and Okumura K, Ikebe M and Takeshita M wrote the paper.
Correspondence to: Kenji Okumura, MD, Department of Surgery, Nippon Steel Yawata Memorial Hospital, 1-1-1, Harunomachi, Yahatahigashi-ku, Kitakyushu 805-8508, Japan. kenjiokumura@kyudai.jp
Telephone: +81-93-6723176 Fax: +81-93-6719605
Received: April 25, 2011 Revised: June 15, 2011 Accepted: April 12, 2012 Published online: May 21, 2012
Abstract
Enteropathy-associated T-cell lymphoma (EATL) is a rare peripheral T-cell lymphoma classified into 2 types, with or without celiac disease, based on histology. Type 2 EATL is less commonly associated with celiac disease, in which cells are characterized by being monomorphic and small- to medium-sized. Cells are characterized by CD8 and CD56 expression and c-MYC oncogene locus gain. We present an atypical case of type 2 EATL in the jejunum, with human T-lymphotropic virus-1 that was CD4- CD8+ CD56- CD30- CD25- TIA-1+ and granzyme B+ on immunohistological staining. It also displayed translocation of chromosome 8p24 (c-MYC), as determined by fluorescent in situ hybridization. Mucosal spreading and intraepithelial invasion by lymphoma with villous atrophy were detected adjacent to the mucosal layer. The lymphoma may be derived from intraepithelial CD8+ T cells, similar to celiac disease.
