Brief Article
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World J Gastroenterol. Feb 28, 2011; 17(8): 1071-1075
Published online Feb 28, 2011. doi: 10.3748/wjg.v17.i8.1071
Hyperthermic intraperitoneal chemotherapy for gastric and colorectal cancer in Mainland China
Tao Suo, Haile Mahteme, Xin-Yu Qin
Tao Suo, Xin-Yu Qin, Department of General Surgery, Zhongshan Hospital, Fudan University, General Surgery Institute of Fudan University, Shanghai 200032, China
Haile Mahteme, Department of Surgical Sciences, Uppsala University, SE75185 Uppsala, Sweden
Author contributions: Suo T and Qin XY designed the study; Suo T performed the search of the literature and analyzed the data; Suo T and Mahteme H wrote the paper; Qin XY revised the paper before submission.
Correspondence to: Xin-Yu Qin, MD, PhD, Department of General Surgery, Zhongshan Hospital, Fudan University, General Surgery Institute of Fudan University, 180 Fenglin Road, Xuhui District, Shanghai 200032, China. qin.xinyu@live.cn
Telephone: +86-21-64041990 Fax: +86-21-64037224
Received: August 12, 2010
Revised: October 11, 2010
Accepted: October 18, 2010
Published online: February 28, 2011
Abstract

AIM: To investigate the current status of peritoneal carcinomatosis (PC) management, as well as the usage of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in mainland China.

METHODS: A potentially curative therapeutic strategy for selecting patients with PC, known as “Techniques”, consists of CRS in combination with HIPEC. A systemic search of published works and clinical trials was performed. Additional papers were retrieved by cross-checking references and obtaining information from Chinese oncologists and relevant conferences. One hundred and one papers and one registered clinical trial on HIPEC were included.

RESULTS: A literature review identified 86 hospitals in 25 out of all 31 areas of mainland China that perform HIPEC. The earliest report included in our survey was published in 1993. Different approaches to HIPEC have been utilized, i.e. palliative, prophylactic, and possibly curative treatment. Only one center has consistently performed HIPEC according to the “Sugarbaker Protocol”, which involves evaluating the extent of PC with peritoneal cancer index and the results of CRS with the completeness of cytoreduction. Positive preliminary results were reported: 7 of 21 patients with PC survived, free of tumors, during an 8-43-mo follow-up period. Hyperthermic strategies that include HIPEC have been practiced for a long time in mainland China, whereas the “Sugarbaker Protocol/Techniques” has been only rarely implemented in China. The Peritoneal Surface Oncology Group International hosts a biannual workshop with the intent to train more specialists in this field and provide support for the construction of quality treatment centers, especially in developing countries like China, whose population is huge and has a dramatically increased incidence of cancer.

CONCLUSION: To popularize Sugarbaker Protocol/Techniques in mainland China in PC management arising from gastric cancer or colorectal cancer will be the responsibility of the upcoming Chinese Peritoneal Surface Oncology Group.

Keywords: Peritoneal carcinomatosis; Hyperthermia; Prophylactic strategy; Sugarbaker Protocol/techniques; Mainland China