Brief Article
Copyright ©2011 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Feb 28, 2011; 17(8): 1030-1035
Published online Feb 28, 2011. doi: 10.3748/wjg.v17.i8.1030
NSAID-induced deleterious effects on the proximal and mid small bowel in seronegative spondyloarthropathy patients
Mihai Rimbaş, Mădălina Marinescu, Mihail Radu Voiosu, Cristian Răsvan Băicuş, Simona Caraiola, Adriana Nicolau, Doina Niţescu, Georgeta Camelia Badea, Magda Ileana Pârvu
Mihai Rimbaş, Mădălina Marinescu, Mihail Radu Voiosu, Department of Gastroenterology, “N.Gh.Lupu” Clinic of Internal Medicine, “Carol Davila” University of Medicine and Pharmacy, Colentina Clinical Hospital, 020125 Bucharest, Romania
Cristian Răsvan Băicuş, Simona Caraiola, Adriana Nicolau, Doina Niţescu, Georgeta Camelia Badea, Department of Internal Medicine, “N.Gh.Lupu” Clinic of Internal Medicine, “Carol Davila” University of Medicine and Pharmacy, Colentina Clinical Hospital, 020125 Bucharest, Romania
Magda Ileana Pârvu, Department of Rheumatology, Colentina Clinical Hospital, 020125 Bucharest, Romania
Author contributions: All authors contributed to this work; Rimbaş M and Voiosu MR designed the research; Caraiola S, Nicolau A, Niţescu D, Badea GC and Pârvu MI recruited the patients; Rimbaş M and Marinescu M performed the research; Rimbaş M and Băicuş CR analyzed the data; Rimbaş M wrote the paper.
Supported by CNCSIS-UEFISCSU, Romanian Ministry of Education and Research, project number PNII-IDEI 320/2007, and is part of a study registered on ClinicalTrials.gov with the number NCT00768950
Correspondence to: Mihai Rimbaş, MD, Teaching Assistant, Department of Gastroenterology, “N.Gh.Lupu” Clinic of Internal Medicine, “Carol Davila” University of Medicine and Pharmacy, Colentina Clinical Hospital, 19-21 Ştefan cel Mare Street, 020125 Bucharest, Romania. mrimbas@yahoo.com
Telephone: +40-21-3180604 Fax: +40-31-8162376
Received: August 15, 2010
Revised: November 11, 2010
Accepted: November 18, 2010
Published online: February 28, 2011
Abstract

AIM: To investigate the small bowel of seronegative spondyloarthropathy (SpA) patients in order to ascertain the presence of mucosal lesions.

METHODS: Between January 2008 and June 2010, 54 consecutive patients were enrolled and submitted to avideo capsule endoscopy (VCE) examination. History and demographic data were taken, as well as the history of non-steroidal anti-inflammatory drug (NSAID) consumption. After reading each VCE recording, a capsule endoscopy scoring index for small bowel mucosal inflammatory change (Lewis score) was calculated. Statistical analysis of the data was performed.

RESULTS: The Lewis score for the whole cohort was 397.73. It was higher in the NSAID consumption subgroup (P = 0.036). The difference in Lewis score between NSAID users and non-users was reproduced for the first and second proximal tertiles of the small bowel, but not for its distal third (P values of 0.036, 0.001 and 0.18, respectively). There was no statistical significant difference between the groups with regard to age or sex of the patients.

CONCLUSION: The intestinal inflammatory involvement of SpA patients is more prominent in NSAID users for the proximal/mid small bowel, but not for its distal part.

Keywords: Videocapsule endoscopy; Lewis score; Non-steroidal anti-inflammatory drugs; Small bowel mucosal injury; Spondyloarthropathy