Rimbaş M, Marinescu M, Voiosu MR, Băicuş CR, Caraiola S, Nicolau A, Niţescu D, Badea GC, Pârvu MI. NSAID-induced deleterious effects on the proximal and mid small bowel in seronegative spondyloarthropathy patients. World J Gastroenterol 2011; 17(8): 1030-1035 [PMID: 21448355 DOI: 10.3748/wjg.v17.i8.1030]
Corresponding Author of This Article
Mihai Rimbaş, MD, Teaching Assistant, Department of Gastroenterology, “N.Gh.Lupu” Clinic of Internal Medicine, “Carol Davila” University of Medicine and Pharmacy, Colentina Clinical Hospital, 19-21 Ştefan cel Mare Street, 020125 Bucharest, Romania. mrimbas@yahoo.com
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Feb 28, 2011; 17(8): 1030-1035 Published online Feb 28, 2011. doi: 10.3748/wjg.v17.i8.1030
NSAID-induced deleterious effects on the proximal and mid small bowel in seronegative spondyloarthropathy patients
Mihai Rimbaş, Mădălina Marinescu, Mihail Radu Voiosu, Cristian Răsvan Băicuş, Simona Caraiola, Adriana Nicolau, Doina Niţescu, Georgeta Camelia Badea, Magda Ileana Pârvu
Mihai Rimbaş, Mădălina Marinescu, Mihail Radu Voiosu, Department of Gastroenterology, “N.Gh.Lupu” Clinic of Internal Medicine, “Carol Davila” University of Medicine and Pharmacy, Colentina Clinical Hospital, 020125 Bucharest, Romania
Cristian Răsvan Băicuş, Simona Caraiola, Adriana Nicolau, Doina Niţescu, Georgeta Camelia Badea, Department of Internal Medicine, “N.Gh.Lupu” Clinic of Internal Medicine, “Carol Davila” University of Medicine and Pharmacy, Colentina Clinical Hospital, 020125 Bucharest, Romania
Magda Ileana Pârvu, Department of Rheumatology, Colentina Clinical Hospital, 020125 Bucharest, Romania
Author contributions: All authors contributed to this work; Rimbaş M and Voiosu MR designed the research; Caraiola S, Nicolau A, Niţescu D, Badea GC and Pârvu MI recruited the patients; Rimbaş M and Marinescu M performed the research; Rimbaş M and Băicuş CR analyzed the data; Rimbaş M wrote the paper.
Supported by CNCSIS-UEFISCSU, Romanian Ministry of Education and Research, project number PNII-IDEI 320/2007, and is part of a study registered on ClinicalTrials.gov with the number NCT00768950
Correspondence to: Mihai Rimbaş, MD, Teaching Assistant, Department of Gastroenterology, “N.Gh.Lupu” Clinic of Internal Medicine, “Carol Davila” University of Medicine and Pharmacy, Colentina Clinical Hospital, 19-21 Ştefan cel Mare Street, 020125 Bucharest, Romania. mrimbas@yahoo.com
Telephone: +40-21-3180604 Fax: +40-31-8162376
Received: August 15, 2010 Revised: November 11, 2010 Accepted: November 18, 2010 Published online: February 28, 2011
Abstract
AIM: To investigate the small bowel of seronegative spondyloarthropathy (SpA) patients in order to ascertain the presence of mucosal lesions.
METHODS: Between January 2008 and June 2010, 54 consecutive patients were enrolled and submitted to avideo capsule endoscopy (VCE) examination. History and demographic data were taken, as well as the history of non-steroidal anti-inflammatory drug (NSAID) consumption. After reading each VCE recording, a capsule endoscopy scoring index for small bowel mucosal inflammatory change (Lewis score) was calculated. Statistical analysis of the data was performed.
RESULTS: The Lewis score for the whole cohort was 397.73. It was higher in the NSAID consumption subgroup (P = 0.036). The difference in Lewis score between NSAID users and non-users was reproduced for the first and second proximal tertiles of the small bowel, but not for its distal third (P values of 0.036, 0.001 and 0.18, respectively). There was no statistical significant difference between the groups with regard to age or sex of the patients.
CONCLUSION: The intestinal inflammatory involvement of SpA patients is more prominent in NSAID users for the proximal/mid small bowel, but not for its distal part.
