Chang CC, Chen CC, Chiu HF, Yang CY. Higher parity associated with higher risk of death from gastric cancer. World J Gastroenterol 2011; 17(6): 784-788 [PMID: 21390150 DOI: 10.3748/wjg.v17.i6.784]
Corresponding Author of This Article
Chun-Yuh Yang, PhD, MPH, Faculty of Public Health, Kaohsiung Medical University, 100 Shih-Chuan 1st RD, Kaohsiung 80708, Taiwan, China. chunyuh@kmu.edu.tw
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Feb 14, 2011; 17(6): 784-788 Published online Feb 14, 2011. doi: 10.3748/wjg.v17.i6.784
Higher parity associated with higher risk of death from gastric cancer
Chih-Ching Chang, Chih-Cheng Chen, Hui-Fen Chiu, Chun-Yuh Yang
Chih-Ching Chang, Department of Environmental and Occupational Health, National Cheng Kung University, Tainan 70154, Taiwan, China
Chih-Cheng Chen, Department of Pediatrics, Chang-Gung Memorial Hospital, Kaohsiung Medical Center, Chang-Gung University, College of Medicine, Kaohsiung 80708, Taiwan, China
Hui-Fen Chiu, Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, China
Chun-Yuh Yang, Faculty of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, China
Chun-Yuh Yang, Division of Environmental Health and Occupational Medicine, National Health Research Institute, Miaoli 36051, Taiwan, China
Author contributions: Chang CC did the statistical analysis and wrote the manuscript; Chen CC and Chiu HF provided essential insight into the interpretation of the results; Yang CY contributed to the study design and interpretation of the data, He had full access to all of the data in the study, and took responsibility for the integrity of the data and the accuracy of the data analysis.
Supported by A grant from the National Science Council, Executive Yuan, Taiwan, No. NSC-94-2314-B-037-056
Correspondence to: Chun-Yuh Yang, PhD, MPH, Faculty of Public Health, Kaohsiung Medical University, 100 Shih-Chuan 1st RD, Kaohsiung 80708, Taiwan, China. chunyuh@kmu.edu.tw
Telephone: +886-7-3121101 Fax: +886-7-3110811
Received: October 14, 2010 Revised: December 27, 2010 Accepted: January 4, 2011 Published online: February 14, 2011
Abstract
AIM: To examine the association between parity and gastric cancer (the cases are almost all premenopausal women) risk in a cohort of young parous women.
METHODS: The study cohort consisted of all women with a record of a first and singleton childbirth in the Birth Register between 1978 and 1987. We tracked each woman from the time of her first childbirth to December 31, 2008. Their vital status was ascertained by linking records to the computerized mortality database. Cox proportional hazard regression models were used to estimate hazard ratios of death from gastric cancer associated with parity.
RESULTS: There were 1090 gastric cancer deaths (85.87% of them were premenopausal) during 33 686 828 person-years of follow-up. The mortality rate of gastric cancer was 3.24 cases per 100 000 person-years. A trend of increasing risk of gastric cancer was seen with increasing parity. The adjusted hazard ratio was 1.24 [confidence interval (95% CI): 1.02-1.50] for women who had borne two to three children, and 1.32 (95% CI: 1.01-1.72) for women with four or more births, when compared with women who had given birth to only one child.
CONCLUSION: These results suggest that higher parity may increase the risk of death from gastric cancer among premenopausal women.
