Chen YW, Chen HH, Wang TE, Chang CW, Chang CW, Wu CJ. Difference between CKD-EPI and MDRD equations in calculating glomerular filtration rate in patients with cirrhosis. World J Gastroenterol 2011; 17(40): 4532-4538 [PMID: 22110285 DOI: 10.3748/wjg.v17.i40.4532]
Corresponding Author of This Article
Dr. Chih-Jen Wu, Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, No. 92, sec 2, Zhongshan N Rd, Zhongshan Dist, Taipei 10449, Taiwan. yw.chen.mmh@gmail.com
Article-Type of This Article
Brief Article
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Han-Hsiang Chen, National Taipei College of Nursing, Taipei 10449, Taiwan
Tsang-En Wang, Ching-Wei Chang, Chen-Wang Chang, Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei 10449, Taiwan
Chih-Jen Wu, Graduate Institute of Medical Science, Taipei Medical University, Taipei 11031, Taiwan
Author contributions: Chen YW, Chen HH, Chang CW and Wu CJ designed the research; Chen YW, Chang CW and Chang CW performed the research; Chen YW and Chen HH contributed new reagents/analytic tools; Chen YW, Wang TE and Chang CW analyzed the data; and Chen YW wrote the paper.
Correspondence to: Dr. Chih-Jen Wu, Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, No. 92, sec 2, Zhongshan N Rd, Zhongshan Dist, Taipei 10449, Taiwan. yw.chen.mmh@gmail.com
Telephone: +886-2-25433535 Fax: +886-2-25433642
Received: January 6, 2011 Revised: June 15, 2011 Accepted: June 22, 2011 Published online: October 28, 2011
Abstract
AIM: To evaluate the difference between the performance of the (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations in cirrhotic patients.
METHODS: From Jan 2004 to Oct 2008, 4127 cirrhotic patients were reviewed. Patients with incomplete data with respect to renal function were excluded; thus, a total of 3791 patients were included in the study. The glomerular filtration rate (GFR) was estimated by the 4-variable MDRD (MDRD-4), 6-variable MDRD (MDRD-6), and CKD-EPI equations.
RESULTS: When serum creatinine was 0.7-6.8 mg/dL and 0.6-5.3 mg/dL in men and women, respectively, a significantly lower GFR was estimated by the MDRD-6 than by the CKD-EPI. Similar GFRs were calculated by both equations when creatinine was > 6.9 mg/dL and > 5.4 mg/dL in men and women, respectively. In predicting in-hospital mortality, estimated GFR obtained by the MDRD-6 showed better accuracy [81.72%; 95% confidence interval (CI), 0.94-0.95] than that obtained by the MDRD-4 (80.22%; 95%CI, 0.96-0.97), CKD-EPI (79.93%; 95%CI, 0.96-0.96), and creatinine (77.50%; 95%CI, 2.27-2.63).
CONCLUSION: GFR calculated by the 6-variable MDRD equation may be closer to the true GFR than that calculated by the CKD-EPI equation.
