Gao F, Gu YK, Fan WJ, Zhang L, Huang JH. Evaluation of transarterial chemoembolization combined with percutaneous ethanol ablation for large hepatocellular carcinoma. World J Gastroenterol 2011; 17(26): 3145-3150 [PMID: 21912458 DOI: 10.3748/wjg.v17.i26.3145]
Corresponding Author of This Article
Dr. Jin-Hua Huang, Department of Medical Imaging and Interventional Radiology, Cancer Center, Sun Yat-Sen University, 651 East Dongfeng Road, Guangzhou 510060, Guangdong Province, China. hjinh@mail.sysu.edu.cn
Article-Type of This Article
Brief Article
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Fei Gao, Yang-Kui Gu, Wei-Jun Fan, Liang Zhang, Jin-Hua Huang, State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong Province, China
Fei Gao, Yang-Kui Gu, Wei-Jun Fan, Liang Zhang, Jin-Hua Huang, Department of Medical Imaging and Interventional Radiology, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong Province, China
Author contributions: Gao F and Gu YK performed the majority of study; Fan WJ provided financial support and collected cases; Zhang L provided analytical tools and edited the manuscript; Huang JH designed the study and wrote the manuscript.
Supported by Guangdong Provincial Science and Technology Project, China, No. 2008B030301127
Correspondence to: Dr. Jin-Hua Huang, Department of Medical Imaging and Interventional Radiology, Cancer Center, Sun Yat-Sen University, 651 East Dongfeng Road, Guangzhou 510060, Guangdong Province, China. hjinh@mail.sysu.edu.cn
Telephone: +86-20-87343272 Fax: +86-20-87343272
Received: January 23, 2011 Revised: March 24, 2011 Accepted: March 31, 2011 Published online: July 14, 2011
Abstract
AIM: To assess the effects of combined transcatheter arterial chemoembolization (TACE) and percutaneous ethanol ablation (PEA) in patients with large hepatocellular carcinoma (HCC).
METHODS: A total of 63 patients with unresectable large HCC were treated with TACE followed by PEA. The largest dimension of the tumors ranged from 5.3 cm to 17.8 cm. The survival rates, acute effects, toxicity and prognostic factors were analyzed.
RESULTS: The cumulative survival rates at 1, 3 and 5 years were 59.4%, 28.4% and 15.8%, respectively (a median survival of 27.7 mo). Tumor area was reduced by more than 50% in 30 (47.6%) cases. In 56 cases with increased α-fetoprotein (AFP) values, AFP level was declined by more than 75%. The combined therapy was generally well tolerated. Only two patients died from variceal bleeding associated with the therapy. The Cox proportional hazards model showed that the number of tumors, the tumor margin and the ethanol dose were independent prognostic factors.
CONCLUSION: The combined TACE and PEA therapy is a promising approach for unresectable large HCC.
