Wang CF, Wang ZY, Li JY. Dual protective role of HO-1 in transplanted liver grafts: A review of experimental and clinical studies. World J Gastroenterol 2011; 17(26): 3101-3108 [PMID: 21912452 DOI: 10.3748/wjg.v17.i26.3101]
Corresponding Author of This Article
Ji-Yu Li, PhD, Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China. leejiyu@sina.com
Article-Type of This Article
Review
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World J Gastroenterol. Jul 14, 2011; 17(26): 3101-3108 Published online Jul 14, 2011. doi: 10.3748/wjg.v17.i26.3101
Dual protective role of HO-1 in transplanted liver grafts: A review of experimental and clinical studies
Chun-Feng Wang, Zhen-Yu Wang, Ji-Yu Li
Chun-Feng Wang, Zhen-Yu Wang, Ji-Yu Li, Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China
Author contributions: Wang CF, Wang ZY and Li JY contributed equally to this work; Li JY and Wang ZY conceived the paper and made some good suggestions; Wang CF wrote the paper.
Supported by The grants for Young Scientist Project, National Natural Science Foundation of China, No. 30600598; “Qi Ming Star for Young Scientist” Project, Science and Technology Commission of Shanghai Municipality, No. 10QH1401800; “Shu Guang Scholar” Project, Shanghai Municipal Educational Commission, No. 10SG20; the Key Medical Project of Science and Technology Commission of Shanghai Municipality, No. 09411952500; Nano-specific Project of Science and Technology Commission of Shanghai Municipality, Project No. 0952nm03800; and Research and Innovation Project of Shanghai Municipal Education Commission, Project No. 09YZ103
Correspondence to: Ji-Yu Li, PhD, Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China. leejiyu@sina.com
Received: January 18, 2011 Revised: February 2, 2011 Accepted: February 9, 2011 Published online: July 14, 2011
Abstract
Liver transplantation is considered as the most effective treatment for end-stage liver disease. However, serious complications still exist, particularly in two aspects: ischemia and subsequent reperfusion of the liver, causing postoperative hepatic dysfunction and even failure; and acute and chronic graft rejections, affecting the allograft survival. Heme oxygenase (HO), a stress-response protein, is believed to exert a protective function on both the development of ischemia-reperfusion injury (IRI) and graft rejection. In this review of current researches on allograft protection, we focused on the HO-1. We conjecture that HO-1 may link these two main factors affecting the prognosis of liver transplantations. In this review, the following aspects were emphasized: the basic biological functions of HO-1, its roles in IRI and allograft rejection, as well as methods to induce HO-1 and the prospects of a therapeutic application of HO-1 in liver transplantation.
