Systematic review on the surgical treatment for T1 gallbladder cancer

doi:10.3748/wjg.v17.i2.174

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Jan 14, 2011 (publication date) through Apr 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Original Article

World J Gastroenterol. Jan 14, 2011; 17(2): 174-180
Published online Jan 14, 2011. doi: 10.3748/wjg.v17.i2.174

Systematic review on the surgical treatment for T1 gallbladder cancer

Seung Eun Lee, Jin-Young Jang, Chang-Sup Lim, Mee Joo Kang, Sun-Whe Kim

Seung Eun Lee, Department of Surgery, Chung-Ang University College of Medicine, Seoul, 140-757, South Korea

Jin-Young Jang, Chang-Sup Lim, Mee Joo Kang, Sun-Whe Kim, Department of Surgery, Seoul National University College of Medicine, Seoul, 110-744, South Korea

Author contributions: Lee SE, Jang JY, Lim CS, Kang MJ and Kim SW designed research; Lee SE, Kang MJ and Lim CS performed research; Lee SE and Jang JY analyzed the data; Lee SE wrote the paper.

Correspondence to: Jin-Young Jang, MD, PhD, Department of Surgery, Seoul National University College of Medicine, 28 Yeongeon-dong, Jongno-gu, Seoul, 110-744, South Korea. jangjy4@snu.ac.kr

Telephone: +82-2-20722194 Fax: +82-2-7412194

Received: August 12, 2010
Revised: September 9, 2010
Accepted: September 16, 2010
Published online: January 14, 2011

Abstract

AIM: To evaluate the efficacy of simple and extended cholecystectomy for mucosa (T1a) or muscularis (T1b) gallbladder (GB) cancer.

METHODS: Original studies on simple and extended cholecystectomy for T1a or T1b GB cancer were searched from MEDLINE (PubMed), Cochrane Library, EMBase, and CancerLit using the search terms of GB, cancer/carcinoma/tumor/neoplasm.

RESULTS: Twenty-nine out of the 2312 potentially relevant publications met the eligibility criteria. Of the 1266 patients with GB cancer included in the publications, 706 (55.8%) and 560 (44.2%) had T1a and T1b GB cancer, respectively. Simple cholecystectomy for T1a and T1b GB cancer was performed in 590 (83.6%) and 375 (67.0%) patients, respectively (P < 0.01). In most series, the treatment of choice was simple cholecystectomy for T1a GB cancer patients with a 5-year survival rate of 100%. Lymph node metastasis was detected in 10.9% of the T1b GB cancer patients and in 1.8% of the T1a GB cancer patients, respectively (P < 0.01). Eight patients (1.1%) with T1a GB cancer and 52 patients (9.3%) with T1b GB cancer died of recurrent GB cancer (P < 0.01).

CONCLUSION: Simple cholecystectomy represents the adequate treatment of T1a GB cancer. There is no definite evidence that extended cholecystectomy is advantageous over simple cholecystectomy for T1b GB cancer.

Keywords: Gallbladder, Cancer, Cholecystectomy, Simple, Extended