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©2011 Baishideng Publishing Group Co., Limited. All rights reserved.
Monoclonal immunoscintigraphy for detection of metastasis and recurrence of colorectal cancer
Vera Artiko, Ana Koljevic Marković, Dragana Šobić-Šaranović, Milorad Petrović, Andrija Antić, Mirjana Stojković, Marinko Žuvela, Djordjije Šaranović, Milica Stojković, Nebojša Radovanović, Danijel Galun, Aleksandar Milovanović, Jovica Milovanović, Anica Bobić-Radovanović, Zoran Krivokapic, Vladimir Obradović
Vera Artiko, Dragana Šobić-Šaranović, Milorad Petrović, Andrija Antić, Mirjana Stojković, Marinko Žuvela, Djordjije Šaranović, Milica Stojković, Nebojša Radovanović, Danijel Galun, Jovica Milovanović, Anica Bobić-Radovanović, Zoran Krivokapic, Vladimir Obradović, School of Medicine, University of Belgrade, Clinical Center of Serbia, Visegradska 26, 11 000 Belgrade, Serbia
Ana Koljevic Marković, National Research Cancer Center, Pasterova 2, 11 000 Belgrade, Serbia
Aleksandar Milovanović, Institute for Ocupational Medicine, Belgrade University School of Medicine, Paterova 2, 11000 Belgrade, Serbia
Author contributions: Artiko V, Markovic AK, Šobić-Šaranović D, Petrović M, Antić A, Stojković M, Žuvela M, Šaranović D, Krivokapic Z and Obradović V contributed equally to this work; Artiko V, Marković AK, Šobić-Šaranović D, Petrović M, Šaranović D, Krivokapić Z and Obradović V designed the research; Artiko V, Marković AK, Šobić-Šaranović D, Petrović M, Antić A, Stojković M, Žuvela M, Stojković M, Radovanović N, Milovanović A, Milovanović J, Bobić-Radovanović A and Galun D,collected the data; Artiko V and Markovic AK wrote the paper.
Supported by A Grant of the Ministry of Science of the Republic of Serbia, No.175018
Correspondence to: Dr. Vera Artiko, Professor, Center for Nuclear Medicine, Clinical Center of Serbia, Visegradska 26, 11 000 Belgrade, Serbia.
veraart@beotel.net
Telephone: +381-11-3615641 Fax: +381-11-3615641
Received: October 6, 2010
Revised: December 23, 2010
Accepted: December 30, 2010
Published online: May 21, 2011
AIM: To assess the clinical role of monoclonal immunoscintigraphy for the detection of metastasis and recurrence of colorectal cancer.
METHODS: Monoclonal immunoscintigraphy was performed in patients operated on for colorectal adenocarcinoma suspected of local recurrence and metastatic disease. The results were compared with conventional diagnostics.
RESULTS: Immunoscintigraphic investigation was done in 53 patients. Tumor recurrence occurred in 38 patients, and was confirmed by other diagnostic modalities in 35. In 15 patients, immunoscintigraphic findings were negative, and confirmed in 14 with other diagnostic methods. Comparative analysis confirmed good correlation of immunoscintigraphic findings and the results of conventional diagnostics and the level of tumor marker carcinoembryonic antigen. Statistical analysis of parameters of radiopharmaceutical groups imacis, indimacis and oncoscint presented homogenous characteristics all of three radiopharmaceuticals. The analysis of immunoscintigraphic target focus was clearly improved using tomography.
CONCLUSION: Immunoscintigraphy is highly specific and has a good predictive value in local recurrence of colorectal cancer.
