Original Article
Copyright ©2011 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. May 14, 2011; 17(18): 2326-2331
Published online May 14, 2011. doi: 10.3748/wjg.v17.i18.2326
LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese
Rui Chen, Fu-Kang Luo, Ya-Li Wang, Jin-Liang Tang, You-Sheng Liu
Rui Chen, You-Sheng Liu, Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
Fu-Kang Luo, Department of Laboratory Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
Ya-Li Wang, Jin-Liang Tang, Department of Pathology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
Author contributions: Chen R and Liu YS designed research; Chen R and Luo FK performed research; Wang YL and Tang JL provided new reagents/analytic tools; Chen R, Liu YS and Luo FK analyzed data; and Chen R and Liu YS wrote the paper.
Supported by The National Natural Science Foundation of China, No.30571924
Correspondence to: You-Sheng Liu, PhD, Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. ysliu01@yahoo.com.cn
Telephone: +86-23-68765460 Fax: +86-23-68765460
Received: February 21, 2011
Revised: April 11, 2011
Accepted: April 18, 2011
Published online: May 14, 2011
Abstract

AIM: To explore the associations of polymorphisms of lipopolysaccharide binding protein (LBP), cluster of differentiation 14 (CD14), toll-like receptor 4 (TLR-4), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) with the colorectal carcinoma (CRC) risk in Han Chinese.

METHODS: Polymorphisms of LBP (rs1739654, rs2232596, rs2232618), CD14 (rs77083413, rs4914), TLR-4 (rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721) were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. Single-nucleotide polymorphisms (SNPs) between cases and controls were analyzed by unconditional logistic regression.

RESULTS: GA and GG genotypes of LBP rs2232596 were associated with a significantly increased risk of CRC [odds ratio (OR) = 1.51, 95% confidence interval (CI) 1.15-1.99, P = 0.003; OR = 2.49, 95% CI 1.16-5.38, P = 0.016, respectively]. A similar association was also observed for the CG genotype of CD14 rs4914 (OR= 1.69, 95% CI 1.20-2.36, P = 0.002). In addition, a combination of polymorphisms in LBP rs2232596 and CD14 rs4914 led to a 3.4-fold increased risk of CRC (OR = 3.44, 95% CI 1.94-6.10, P = 0.000).

CONCLUSION: This study highlights the LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population.

Keywords: Colorectal carcinoma; Cluster of differentiation 14; Lipopolysaccharide binding protein; Single-nucleotide polymorphisms