Brief Article
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World J Gastroenterol. Apr 28, 2011; 17(16): 2109-2112
Published online Apr 28, 2011. doi: 10.3748/wjg.v17.i16.2109
Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer
Ozgur Kemik, Ahu Sarbay Kemik, Aziz Sümer, Ahmet Cumhur Dulger, Mine Adas, Huseyin Begenik, Ismail Hasirci, Ozkan Yilmaz, Sevim Purisa, Erol Kisli, Sefa Tuzun, Cetin Kotan
Ozgur Kemik, Aziz Sümer, Ismail Hasirci, Ozkan Yilmaz, Erol Kisli, Cetin Kotan, Department of General Surgery, Yuzuncu Yıl University Medical Faculty, Van, 6500, Turkey
Ahu Sarbay Kemik, Department of Biochemistry, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, 3400, Turkey
Ahmet Cumhur Dulger, Department of Gastroenterology, Medical Faculty, University of Yüzüncü Yıl, Van, 6500, Turkey
Mine Adas, Department of Endocrinology, Okmeydani Education and Research Hospital, Istanbul, 3400, Turkey
Huseyin Begenik, Department of Internal Medicine, Medical Faculty, University of Yüzüncü Yıl, Van, 6500, Turkey
Sevim Purisa, Department of Biostatistics, Istanbul Medical Faculty, University of Istanbul, Istanbul, 3400, Turkey
Sefa Tuzun, II. General Surgery, Haseki Education and Research Hospital, Istanbul, 3400, Turkey
Author contributions: Kemik O, Kemik AS and Sümer A designed the study and wrote the paper; Kemik AS performed the biochemical evaluation, and collected and analyzed the data; Purisa S performed the statistical analyzis; Adas M, Begenik H, Yilmaz O, Hasirci I, Dulger AC, Kisli E, Tuzun S and Kotan C contributed to the discussion.
Correspondence to: Ozgur Kemik, MD, Assistant Professor, Department of General Surgery, Yuzuncu Yıl University Medical Faculty, Van, 6500, Turkey. ozgurkemik@hotmail.com
Telephone: +90-432-2251024 Fax: +90-432-2164705
Received: August 10, 2010
Revised: January 18, 2011
Accepted: January 25, 2011
Published online: April 28, 2011
Abstract

AIM: To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer.

METHODS: One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study. The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay.

RESULTS: Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001). Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance, tumor size, depth of wall invasion, lymph node metastasis, liver metastasis, perineural invasion, and pathological stage. They were not significantly associated with age, gender, tumor location, or histological type.

CONCLUSION: Increased MMP-1 and TIMP-1 were associated with gastric cancer. Although these markers are not good markers for diagnosis, these markers show in advanced gastric cancer.

Keywords: Gastric cancer; Matrix metalloproteinase-1; Tissue matrix metalloproteinase-1