Guo Y, Fang J, Liu Y, Sheng HH, Zhang XY, Chai HN, Jin W, Zhang KH, Yang CQ, Gao HJ. Association between polymorphism rs6983267 and gastric cancer risk in Chinese population. World J Gastroenterol 2011; 17(13): 1759-1765 [PMID: 21483638 DOI: 10.3748/wjg.v17.i13.1759]
Corresponding Author of This Article
Heng-Jun Gao, Professor, National Engineering Center for Biochip at Shanghai, No. 151, Libing Road, Shanghai 201203, China. hengjun_gao@shbiochip.com
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Brief Article
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World J Gastroenterol. Apr 7, 2011; 17(13): 1759-1765 Published online Apr 7, 2011. doi: 10.3748/wjg.v17.i13.1759
Association between polymorphism rs6983267 and gastric cancer risk in Chinese population
Yi Guo, Jing Fang, Yan Liu, Hai-Hui Sheng, Xiao-Yan Zhang, Hai-Na Chai, Wei Jin, Ke-Hao Zhang, Chang-Qing Yang, Heng-Jun Gao
Yi Guo, Hai-Na Chai, Chang-Qing Yang, Heng-Jun Gao, Department of Gastroenterology, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, China
Yi Guo, Hai-Na Chai, Heng-Jun Gao, National Engineering Center for Biochip at Shanghai, Shanghai 201203, China
Jing Fang, Xiao-Yan Zhang, Ke-Hao Zhang, Hai-Hui Sheng, National Engineering Center for Biochip at Shanghai, Shanghai 201203, China
Yan Liu, Wei Jin, Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Author contributions: Guo Y, Fang J, Liu Y and Sheng HH contributed equally to this work; Gao HJ and Sheng HH designed the research; Guo Y, Fang J and Chai HN performed all the experiments; Liu Y, Zhang XY, Jin W and Zhang KH recruited patients and collected information; Guo Y, Fang J and Liu Y analyzed data and wrote the manuscript; Sheng HH, Yang CQ and Gao HJ reviewed the manuscript.
Supported by Shanghai “Phosphor” Science Foundation, China, No. 09QB1403100, the National High Technology Research and Development Program of China, No. 2006AA020704 and 2006AA02A407, the Funds for Key Programs of Ministry of Health of China, No. 2008ZX10002-017
Correspondence to: Heng-Jun Gao, Professor, National Engineering Center for Biochip at Shanghai, No. 151, Libing Road, Shanghai 201203, China. hengjun_gao@shbiochip.com
Telephone: +86-21-51320288 Fax: +86-21-51320287
Received: December 5, 2010 Revised: December 23, 2010 Accepted: December 30, 2010 Published online: April 7, 2011
Abstract
AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk.
METHODS: A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer.
RESULTS: The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively).
CONCLUSION: This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.
