Mainenti PP, Iodice D, Segreto S, Storto G, Magliulo M, Palma GDD, Salvatore M, Pace L. Colorectal cancer and 18FDG-PET/CT: What about adding the T to the N parameter in loco-regional staging? World J Gastroenterol 2011; 17(11): 1427-1433 [PMID: 21472100 DOI: 10.3748/wjg.v17.i11.1427]
Corresponding Author of This Article
Pier Paolo Mainenti, MD, Istituto di Biostrutture e Bioimmagini Consiglio Nazionale delle Ricerche, Via Pansini 5, Naples 80131, Italy. pierpamainenti@hotmail.com
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World J Gastroenterol. Mar 21, 2011; 17(11): 1427-1433 Published online Mar 21, 2011. doi: 10.3748/wjg.v17.i11.1427
Colorectal cancer and 18FDG-PET/CT: What about adding the T to the N parameter in loco-regional staging?
Pier Paolo Mainenti, Delfina Iodice, Sabrina Segreto, Giovanni Storto, Mario Magliulo, Giovanni Domenico De Palma, Marco Salvatore, Leonardo Pace
Pier Paolo Mainenti, Mario Magliulo, Istituto di Biostrutture e Bioimmagini Consiglio Nazionale delle Ricerche, Naples 80131, Italy
Delfina Iodice, Sabrina Segreto, Marco Salvatore, Leonardo Pace, Department of Biomorphological and Functional Sciences, University of Naples “Federico II”, Naples 80131, Italy
Giovanni Storto, Istitituto di Ricovero e Cura a carattere scientifico, Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture 85028 PZ, Italy
Giovanni Domenico De Palma, Department of General Surgery, Geriatry and Endoscopy, University of Naples “Federico II”, Naples 80131, Italy
Author contributions: Mainenti PP, Iodice D and Storto G designed the research; Iodice D, Segreto S and Magliulo M performed the research; De Palma GD and Pace L analyzed the data; Mainenti PP and Salvatore M wrote the paper; Pace L revised the manuscript.
Correspondence to: Pier Paolo Mainenti, MD, Istituto di Biostrutture e Bioimmagini Consiglio Nazionale delle Ricerche, Via Pansini 5, Naples 80131, Italy. pierpamainenti@hotmail.com
Telephone: +39-81-7613060 Fax: +39-81-7616013
Received: August 22, 2010 Revised: October 16, 2010 Accepted: October 23, 2010 Published online: March 21, 2011
Abstract
AIM: To evaluate whether FDG-positron emission tomography (PET)/computed tomography (CT) may be an accurate technique in the assessment of the T stage in patients with colorectal cancer.
METHODS: Thirty four consecutive patients (20 men and 14 women; mean age: 63 years) with a histologically proven diagnosis of colorectal adenocarcinoma and scheduled for surgery in our hospital were enrolled in this study. All patients underwent FDG-PET/CT preoperatively. The primary tumor site and extent were evaluated on PET/CT images. Colorectal wall invasion was analysed according to a modified T classification that considers only three stages (≤ T2, T3, T4). Assessment of accuracy was carried out using 95% confidence intervals for T.
RESULTS: Thirty five/37 (94.6%) adenocarcinomas were identified and correctly located on PET/CT images. PET/CT correctly staged the T of 33/35 lesions identified showing an accuracy of 94.3% (95% CI: 87%-100%). All T1, T3 and T4 lesions were correctly staged, while two T2 neoplasms were overstated as T3.
CONCLUSION: Our data suggest that FDG-PET/CT may be an accurate modality for identifying primary tumor and defining its local extent in patients with colorectal cancer.
