Sun QJ, Liang X, Zheng Q, Gu WQ, Liu WZ, Xiao SD, Lu H. Resistance of Helicobacter pylori to antibiotics from 2000 to 2009 in Shanghai. World J Gastroenterol 2010; 16(40): 5118-5121 [PMID: 20976850 DOI: 10.3748/wjg.v16.i40.5118]
Corresponding Author of This Article
Hong Lu, MD, PhD, Department of Gastroenterology, Shanghai Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine, 145 Shandong Zhong Rd, Shanghai 200001, China. honglu02 @yahoo.com
Article-Type of This Article
Brief Article
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World J Gastroenterol. Oct 28, 2010; 16(40): 5118-5121 Published online Oct 28, 2010. doi: 10.3748/wjg.v16.i40.5118
Resistance of Helicobacter pylori to antibiotics from 2000 to 2009 in Shanghai
Qin-Juan Sun, Xiao Liang, Qing Zheng, Wei-Qi Gu, Wen-Zhong Liu, Shu-Dong Xiao, Hong Lu
Qin-Juan Sun, Xiao Liang, Qing Zheng, Wei-Qi Gu, Wen-Zhong Liu, Shu-Dong Xiao, Hong Lu, Department of Gastroenterology, Shanghai Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China
Author contributions: Sun QJ performed the experiment and wrote the manuscript; Liang X and Zheng Q collected the biopsies; Gu WQ cultured the bacteria; Lu H designed and directed the study and revised the draft; Xiao SD and Liu WZ directed the study.
Supported by National Natural Science Foundation of China, No. 30770112 and Shanghai Leading Academic Discipline Project, No. Y0205
Correspondence to: Hong Lu, MD, PhD, Department of Gastroenterology, Shanghai Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine, 145 Shandong Zhong Rd, Shanghai 200001, China. honglu02 @yahoo.com
Telephone: +86-21-63200874 Fax: +86-21-63266027
Received: May 31, 2010 Revised: June 29, 2010 Accepted: July 6, 2010 Published online: October 28, 2010
Abstract
AIM: To investigate the resistance of Helicobacter pylori (H. pylori) to 6 commonly used antibiotics from 2000 to 2009 in Shanghai.
METHODS: A total of 293 H. pylori strains were collected from 2000 to 2009 in Shanghai and tested for their susceptibility to metronidazole, clarithromycin, amoxicillin, furazolidone, levofloxacin and tetracycline using agar dilution.
RESULTS: The resistant rates of H. pylori to clarithromycin (8.6%, 9.0% and 20.7%) and levofloxacin (10.3%, 24.0% and 32.5%) increased from 2000 to 2009 in Shanghai. The resistant rate of H. pylori to metronidazole remained stable (40%-50%). Only one strain of H. pylori isolated in 2005 was resistant to tetracycline. All strains were sensitive to amoxicillin and furazolidone. The resistant rate of H. pylori to antibiotics was not related with the sex, age and clinical outcome of patients.
CONCLUSION: Resistance of H. pylori to antibiotics plays an important role in making treatment strategies against H. pylori-associated diseases.
