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World J Gastroenterol. Aug 14, 2010; 16(30): 3786-3792
Published online Aug 14, 2010. doi: 10.3748/wjg.v16.i30.3786
Esophageal resection for high-grade dysplasia and intramucosal carcinoma: When and how?
Vani JA Konda, Mark K Ferguson
Vani JA Konda, Department of Medicine, The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, United States
Mark K Ferguson, Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, United States
Author contributions: Konda VJA and Ferguson MK contributed equally to this work.
Correspondence to: Vani JA Konda, MD, Department of Medicine, The University of Chicago Pritzker School of Medicine, 5841 S. Maryland Ave. MC 4076, Chicago, IL 60637, United States. vkonda@medicine.bsd.uchicago.edu
Telephone: +1-773-7021460 Fax: +1-773-7025790
Received: April 24, 2010
Revised: June 7, 2010
Accepted: June 14, 2010
Published online: August 14, 2010
Abstract

High-grade dysplasia (HGD) and intramucosal carcinoma (IMC) in the setting of Barrett’s esophagus have traditionally been treated with esophagectomy. However, with the advent of endoscopic mucosal resection and endoscopic ablative therapies, endoscopic therapy at centers with expertise is now an established treatment of Barrett’s-esophagus-related neoplasia, including HGD and IMC. Esophagectomy is today reserved for more selected cases with submucosal invasion, evidence for lymph node metastasis, or unsuccessful endoscopic therapy.

Keywords: Barrett’s esophagus; High-grade dysplasia; Intramucosal carcinoma; Endoscopic mucosal resection; Esophagectomy