Báez S, Tsuchiya Y, Calvo A, Pruyas M, Nakamura K, Kiyohara C, Oyama M, Yamamoto M. Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women. World J Gastroenterol 2010; 16(3): 372-378 [PMID: 20082485 DOI: 10.3748/wjg.v16.i3.372]
Corresponding Author of This Article
Yasuo Tsuchiya, PhD, Division of Social and Environmental Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan. troof@med.niigata-u.ac.jp
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World J Gastroenterol. Jan 21, 2010; 16(3): 372-378 Published online Jan 21, 2010. doi: 10.3748/wjg.v16.i3.372
Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women
Sergio Báez, Yasuo Tsuchiya, Alfonso Calvo, Martha Pruyas, Kazutoshi Nakamura, Chikako Kiyohara, Mari Oyama, Masaharu Yamamoto
Sergio Báez, Alfonso Calvo, Department of Surgery, Sótero del Río Hospital, Puente Alto, Santiago, Chile
Yasuo Tsuchiya, Kazutoshi Nakamura, Mari Oyama, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan
Martha Pruyas, Department of Anatomic Pathology, Sótero del Río Hospital, Puente Alto, Santiago, Chile
Chikako Kiyohara, Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
Masaharu Yamamoto, Faculty of Health Sciences, Niigata University of Health and Welfare, Niigata 950-3198, Japan
Author contributions: Báez S and Tsuchiya Y contributed equally to this work; Báez S, Tsuchiya Y and Yamamoto M designed the research; Báez S, Tsuchiya Y, Calvo A and Pruyas M performed the research; Nakamura K and Oyama M analyzed the data; Báez S, Tsuchiya Y and Kiyohara C wrote the paper.
Supported by (in part) A Grant-in-Aid for Scientific Research (C) (2007, #19590582) from the Japanese Ministry of Education, Science, Sports and Culture
Correspondence to: Yasuo Tsuchiya, PhD, Division of Social and Environmental Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan. troof@med.niigata-u.ac.jp
Telephone: +81-25-2272121 Fax: +81-25-2270764
Received: September 30, 2009 Revised: November 5, 2009 Accepted: November 12, 2009 Published online: January 21, 2010
Abstract
AIM: To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC).
METHODS: A total of 57 patients with GBC, 119 patients with gallstones, and 70 controls were enrolled in this study. DNA was extracted from their blood or paraffin block sample using standard commercial kits. The statuses of the genetic variants were assayed using Taqman® SNP Genotyping Assays or Custom Taqman® SNP Genotyping Assays.
RESULTS: The non-ancestral T/T genotype of apolipoprotein B rs693 polymorphism was associated with a decreased risk of GBC (OR: 0.14, 95% CI: 0.03-0.63). The T/T genotype of cholesteryl ester transfer protein (CETP) rs708272 polymorphism was associated with an increased risk of GBC (OR: 5.04, 95% CI: 1.43-17.8).
CONCLUSION: Genetic variants involved in gallstone formation such as the apolipoprotein B rs693 and CETP rs708272 polymorphisms may be related to the risk of developing GBC in Chilean women.
