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World J Gastroenterol. Jul 28, 2010; 16(28): 3491-3498
Published online Jul 28, 2010. doi: 10.3748/wjg.v16.i28.3491
Published online Jul 28, 2010. doi: 10.3748/wjg.v16.i28.3491
Protein-protein interaction map is a key gateway into liver regeneration
Chao Xie, Run-Zhi Zhu, Yun-Sheng Yuan, Hong-Lin He, Yan Yu, School of Agriculture and Biology, Shanghai Municipality Key Laboratory of Veterinary Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
Chao Xie, Qiu-Shi Huang, Department of Food Science, Cornell University, Ithaca, NY 14853, United States
Jin Gao, Wei Han, Laboratory of Regeneromics, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
Author contributions: Xie C, Gao J, Zhu RZ, Yuan YS, He HL, Huang QS, Han W and Yu Y contributed equally to this review; Xie C wrote the paper; Gao J, Zhu RZ, Yuan YS and He HL contributed new ideas and some new data; Huang QS, Han W and Yu Y revised the paper; Xie C and Yu Y designed the review.
Supported by Chinese Human Liver Proteome Project, No. 2004BA711A19-08 and National 863 Project, No. 2007AA02Z100
Correspondence to: Yan Yu, PhD, School of Agriculture and Biology, Shanghai Municipality Key Laboratory of Veterinary Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China. yanyu@sjtu.edu.cn
Telephone: +86-21-34205833 Fax: +86-21-34205833
Received: February 2, 2010
Revised: April 6, 2010
Accepted: April 13, 2010
Published online: July 28, 2010
Revised: April 6, 2010
Accepted: April 13, 2010
Published online: July 28, 2010
Abstract
Recent studies indicate that the process of liver regeneration involves multiple signaling pathways and a variety of genes, cytokines and growth factors. Protein-protein interactions (PPIs) play a role in nearly all events that take place within the cell and PPI maps should be helpful in further understanding the process of liver regeneration. In this review, we discuss recent progress in understanding the PPIs that occur during liver regeneration especially those in the transforming growth factor β signaling pathways. We believe the use of large-scale PPI maps for integrating the information already known about the liver regeneration is a useful approach in understanding liver regeneration from the standpoint of systems biology.
Keywords: Liver regeneration; Protein-protein interaction; Protein-protein interaction maps; Transforming growth factor β