D’Onofrio M, Barbi E, Girelli R, Martone E, Gallotti A, Salvia R, Martini PT, Bassi C, Pederzoli P, Mucelli RP. Radiofrequency ablation of locally advanced pancreatic adenocarcinoma: An overview. World J Gastroenterol 2010; 16(28): 3478-3483 [PMID: 20653055 DOI: 10.3748/wjg.v16.i28.3478]
Corresponding Author of This Article
Mirko D’Onofrio, MD, Assistant Professor, Department of Radiology, University Hospital G.B. Rossi, University of Verona, Piazzale L.A. Scuro 10, Verona 37134, Italy. mirko.donofrio@univr.it
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jul 28, 2010; 16(28): 3478-3483 Published online Jul 28, 2010. doi: 10.3748/wjg.v16.i28.3478
Radiofrequency ablation of locally advanced pancreatic adenocarcinoma: An overview
Mirko D’Onofrio, Emilio Barbi, Roberto Girelli, Enrico Martone, Anna Gallotti, Roberto Salvia, Paolo Tinazzi Martini, Claudio Bassi, Paolo Pederzoli, Roberto Pozzi Mucelli
Mirko D’Onofrio, Enrico Martone, Anna Gallotti, Roberto Pozzi Mucelli, Department of Radiology, University Hospital G.B. Rossi, University of Verona, Verona 37134, Italy
Emilio Barbi, Paolo Tinazzi Martini, Department of Radiology, Hospital “Casa di Cura Pederzoli” - Peschiera, Verona 37019, Italy
Roberto Girelli, Department of Surgery, Hospital “Casa di Cura Pederzoli” - Peschiera, Verona 37019, Italy
Roberto Salvia, Claudio Bassi, Paolo Pederzoli, Department of Surgery, University Hospital G.B. Rossi, University of Verona, Verona 37134, Italy
Author contributions: D’Onofrio M, Barbi E, Girelli R, Martone E, Gallotti A, Salvia R, Martini PT, Bassi C, Pederzoli P and Pozzi Mucelli R contributed equally to this work; D’Onofrio M and Gallotti A designed and performed the review; D’Onofrio M, Barbi E and Gallotti A wrote the paper; Pozzi Mucelli R revised the manuscript.
Correspondence to: Mirko D’Onofrio, MD, Assistant Professor, Department of Radiology, University Hospital G.B. Rossi, University of Verona, Piazzale L.A. Scuro 10, Verona 37134, Italy. mirko.donofrio@univr.it
Telephone: +39-45-8124140 Fax: +39-45-8277808
Received: March 10, 2010 Revised: April 2, 2010 Accepted: April 9, 2010 Published online: July 28, 2010
Abstract
Radiofrequency ablation (RFA) of pancreatic neoplasms is restricted to locally advanced, non-resectable but non-metastatic tumors. RFA of pancreatic tumors is nowadays an ultrasound-guided procedure performed during laparotomy in open surgery. Intraoperative ultrasound covers the mandatory role of staging, evaluation of feasibility, guidance and monitoring of the procedure. Different types of needle can be used. The first aim in the evaluation of RFA as a treatment for locally advanced pancreatic ductal adenocarcinoma, in order of evaluation but not of importance, is to determine the feasibility of the procedure. The second aim is to establish the effect of RFA on tumoral mass in terms of necrosis and cytoreduction. The most important aim, third in order of evaluation, is the potential improvement of quality of life and survival rate. Nowadays, only a few studies assess the feasibility of the procedure. The present paper is an overview of RFA for pancreatic adenocarcinoma.
