Hijioka S, Chin K, Seto Y, Yamamoto N, Hatake K. Eight-year survival after advanced gastric cancer treated with S-1 followed by surgery. World J Gastroenterol 2010; 16(22): 2824-2827 [PMID: 20533605 DOI: 10.3748/wjg.v16.i22.2824]
Corresponding Author of This Article
Keisho Chin, MD, Department of Medical Oncology, Cancer Institute Hospital of JFCR, 3-8-31 Ariake Koto-ku, Tokyo 135-8550, Japan. kchin@jfcr.or.jp
Article-Type of This Article
Case Report
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Susumu Hijioka, Keisho Chin, Kiyohiko Hatake, Department of Medical Oncology, Cancer Institute Hospital of JFCR, 3-8-31 Ariake Koto-ku, Tokyo 135-8550, Japan
Yasuyuki Seto, Department of Surgery, Cancer Institute Hospital of JFCR, 3-8-31 Ariake Koto-ku, Tokyo 135-8550, Japan
Noriko Yamamoto, Department of Pathology, Cancer Institute Hospital of JFCR, 3-8-31 Ariake Koto-ku, Tokyo 135-8550, Japan
Author contributions: Hijioka S, Chin K, Hatake K, Seto Y and Yamamoto N designed the work and drafted the manuscript; Chin K and Hatake K revised implementation of the work and reviewed the manuscript critically for intellectual content; Seto Y performed surgery for this case; Yamamoto N performed the pathologic examinations.
Correspondence to: Keisho Chin, MD, Department of Medical Oncology, Cancer Institute Hospital of JFCR, 3-8-31 Ariake Koto-ku, Tokyo 135-8550, Japan. kchin@jfcr.or.jp
Telephone: +81-3-35200111 Fax: +81-3-35700562
Received: February 4, 2010 Revised: March 2, 2010 Accepted: March 9, 2010 Published online: June 14, 2010
Abstract
We report a case of advanced gastric cancer, with cervical, axillary, and abdominal paraaortic lymph node metastases, that was successfully treated with chemotherapy and surgery. The disease was initially considered unresectable, and the patient was treated with orally administered S-1. Chemotherapy was effective, and all lymph node metastases disappeared after 6 courses. After 27 mo of chemotherapy, the patient underwent curative surgery, with subtotal gastrectomy and lymph node dissection. Histopathological examination revealed many viable poorly differentiated adenocarcinoma cells in the stomach, but no cancer cells in the lymph nodes. The patient is alive, without recurrence, 8 years later. This, therefore, is a case report of an 8-year survivor of advanced gastric cancer with distant lymph node metastasis.
