Heme oxygenase-1 system and gastrointestinal tumors

doi:10.3748/wjg.v16.i21.2633

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Jun 7, 2010 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jun 7, 2010; 16(21): 2633-2637
Published online Jun 7, 2010. doi: 10.3748/wjg.v16.i21.2633

Heme oxygenase-1 system and gastrointestinal tumors

Xiao Zhu, Wen-Guo Fan, Dong-Pei Li, Marie CM Lin, Hsiangfu Kung

Xiao Zhu, Institute of Oncology, Affiliated Tumor Hospital of Guangzhou Medical College, Guangzhou 510095, Guangdong Province, China

Wen-Guo Fan, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China

Dong-Pei Li, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China

Marie CM Lin, The Brain Tumor Center and Neurosurgery Division, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China

Hsiangfu Kung, Li Ka Shing Institute of Medical Sciences, the Chinese University of Hong Kong, Shatin, Hong Kong, China

Author contributions: Zhu X, Fan WG, Li DP, Lin MCM and Kung H were responsible for the review of the literature and initial preparation of the paper; Zhu X and Fan WG prepared the final version of the manuscript.

Correspondence to: Xiao Zhu, PhD, Institute of Oncology, Affiliated Tumor Hospital of Guangzhou Medical College, Guangzhou 510095, Guangdong Province, China. bioxzhu@yahoo.com

Telephone: +86-20-83595032 Fax: +86-20-83489984

Received: February 6, 2010
Revised: March 5, 2010
Accepted: March 12, 2010
Published online: June 7, 2010

Abstract

Heme oxygenase-1 (HO-1) system catabolizes heme into three products: carbon monoxide, biliverdin/bilirubin and free iron. It is involved in many physiological and pathophysiological processes. A great deal of data has demonstrated the roles of HO-1 in the formation, growth and metastasis of tumors. The interest in this system by investigators involved in gastrointestinal tumors is fairly recent, and few papers on HO-1 have touched upon this subject. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal tumors studied to date. The implications for possible therapeutic manipulation of HO-1 in gastrointestinal tumors are also discussed.

Keywords: Heme oxygenase-1; Gastrointestinal tumors