Brief Article
Copyright ©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Dec 21, 2009; 15(47): 5992-5999
Published online Dec 21, 2009. doi: 10.3748/wjg.15.5992
Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components
Han-Lin Gong, Wen-Fu Tang, Qin Yu, Jin Xiang, Qing Xia, Guang-Yuan Chen, Xi Huang, Mao-Zhi Liang
Han-Lin Gong, Wen-Fu Tang, Qing Xia, Guang-Yuan Chen, Xi Huang, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Qin Yu, Jin Xiang, Mao-Zhi Liang, Department of Clinical Pharmacology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Gong HL and Tang WF designed the research; Gong HL, Tang WF, Yu Q, Xia Q, Huang X and Liang MZ performed the research; Yu Q, Chen GY and Xiang J analyzed the data; Gong HL and Tang WF wrote the paper.
Supported by The National Natural Science Foundation of China, No. 30400576 and No. 30672588
Correspondence to: Wen-Fu Tang, Professor, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. wftang900@gmail.com
Telephone: +86-28-85422556 Fax: +86-28-85423373
Received: August 28, 2009
Revised: November 2, 2009
Accepted: November 9, 2009
Published online: December 21, 2009
Abstract

AIM: To investigate the effect of severe acute pancreatitis (SAP) on pharmacokinetics of Da-Cheng-Qi Decoction (DCQD) components in rats.

METHODS: Rats were divided into SAP group and sham-operation group as a control group (n = 6). Rhein, chrysophanol, rheochrysidin, magnolol, hesperidin and naringin in DCQD were quantified in rat serum by high performance liquid chromatography tandem mass spectrometry for studying their pharmacokinetics.

RESULTS: Early absorption of each DCQD component was tended to degrade in SAP group after treatment with DCQD by gavage. The Cmax (chrysophanol, P = 0.0059; rheochrysidin, P = 0.0288; magnolol, P = 0.0487; hesperidin, P = 0.0277; naringin, P = 0.0023) and AUC (rhein, P = 0.0186; chrysophanol, P = 0.0013; magnolol, P = 0.001; hesperidin, P = 0.0081; naringin, P = 0.0272) of DCQD component were obviously lower in SAP group than in control group. The T1/2α of chrysophanol and rheochrysidin (P = 0.0467 and 0.0005, respectively) and Tmax of chrysophanol and rheochrysidin (P = 0.0101 and 0.0037, respectively) lasted longer in SAP group than in control group.

CONCLUSION: SAP can significantly impact the absorption of DCQD components in rats and their pharmacokinetic parameters.

Keywords: Severe acute pancreatitis; Da-Cheng-Qi Decoction; Pharmacokinetics; Components