Brief Article
Copyright ©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Dec 7, 2009; 15(45): 5722-5726
Published online Dec 7, 2009. doi: 10.3748/wjg.15.5722
Gastric dysplasia may be an independent risk factor of an advanced colorectal neoplasm
Rack Cheon Bae, Seong Woo Jeon, Han Jin Cho, Min Kyu Jung, Young Oh Kweon, Sung Kook Kim
Rack Cheon Bae, Seong Woo Jeon, Han Jin Cho, Min Kyu Jung, Young Oh Kweon, Sung Kook Kim, Department of Internal Medicine, Kyungpook National University Hospital, 50 Samduk 2-ga, Chung-gu, Daegu 700-721, South Korea
Author contributions: Bae RC and Jeon SW performed the majority of experiments and wrote the manuscript; Cho HJ, Jung MK and Kweon YO provided gastroduodenoscopy, colonoscopic procedures and analytical tools and were also involved in editing the manuscript; Kim SK designed the study.
Correspondence to: Seong Woo Jeon, Assistant Professor, Department of Internal Medicine, Kyungpook National University Hospital, 50 Samduk 2-ga, Chung-gu, Daegu 700-721, South Korea. sw-jeon@hanmail.net
Telephone: +82-53-4205512   Fax: +82-53-4268773
Received: September 14, 2009
Revised: October 14, 2009
Accepted: October 21, 2009
Published online: December 7, 2009
Abstract

AIM: To evaluate the relationship between gastric dysplasia and Helicobacter pylori (H pylori) and the occurrence of colorectal adenoma, and to define the necessity for colonoscopy in patients with gastric dysplasia or H pylori infection.

METHODS: From May 2005 to February 2008, 133 patients with established gastric dysplasia by gastroduodenoscopy (EGD) were additionally investigated by colonoscopy. The authors compared results with those of 213 subjects who underwent both EGD and colonoscopy during the same period at the author’s Health Promotion Center as a control group. H pylori infection was evaluated in both the gastric dysplasia and control groups.

RESULTS: The mean age of all 346 study subjects was 54.1 ± 10.5 years, and there were 258 (73%) men and 87 (27%) women. No significant difference was found between the H pylori positive and negative subjects in terms of the prevalence of colorectal adenoma and advanced colorectal adenoma (P = 0.261). Patients with gastric dysplasia showed no elevated risk of colorectal adenoma (OR = 0.910, 95% CI: 0.587-1.411, P = 0.738), but had a significantly higher risk of having advanced colorectal adenoma (OR = 3.382, 95% CI: 1.700-6.342, P = 0.000).

CONCLUSION: The study emphasizes the need for colon surveillance in patients with gastric dysplasia, regardless of H pylori infection.

Keywords: Gastric adenoma or dysplasia; Helicobacter pylori; Colorectal neoplasm