Brief Article
Copyright ©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Dec 7, 2009; 15(45): 5712-5715
Published online Dec 7, 2009. doi: 10.3748/wjg.15.5712
Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver
Takayuki Takeichi, Shinji Uemoto, Sachiko Minamiguchi, Izumi Takeyoshi, Yukihiro Inomata, Koichi Tanaka, Eiji Kobayashi
Takayuki Takeichi, Shinji Uemoto, Koichi Tanaka, Department of Transplantation and Immunology, Kyoto University Hospital, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Sachiko Minamiguchi, Laboratory of Anatomic Pathology, Kyoto University Hospital, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Takayuki Takeichi, Izumi Takeyoshi, Second Department of Surgery, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan
Takayuki Takeichi, Yukihiro Inomata, Department of Transplantation and Pediatric Surgery, Postgraduate School of Medical Science, Kumamoto University, Kumamoto, 1-1-1 Honjyo, Kumamoto 860-8556, Japan
Eiji Kobayashi, Division of Organ Replacement Research, Center for Molecular Medicine, Jichi Medical School, Minamikawachi-machi, Kawachi-gun, Tochigi 329-0498, Japan
Author contributions: Takeichi T and Uemoto S performed the majority of experiments; Kobayashi E and Inomata Y contributed to the editing of the manuscript; other authors conducted the data collection and analysis.
Correspondence to: Takayuki Takeichi, MD, PhD, Department of Transplantation and Pediatric Surgery, Postgraduate School of Medical Science, Kumamoto University, 1-1-1 Honjyo, Kumamoto 860-8556, Japan. ttakeichi@fc.kuh.kumamoto-u.ac.jp
Telephone: +81-96-3735618 Fax: +81-96-3735618
Received: July 2, 2009
Revised: September 1, 2009
Accepted: September 8, 2009
Published online: December 7, 2009
Abstract

AIM: To investigate the effects of a novel Leukotriene B4 receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model.

METHODS: Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus).

RESULTS: There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more significantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls.

CONCLUSION: This study demonstrated that pretreatment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver ischemia-reperfusion injury.

Keywords: Ischemia-reperfusion injury, Leukotriene B4, Liver, Tacrolimus