Brief Articles
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World J Gastroenterol. Jan 28, 2009; 15(4): 489-495
Published online Jan 28, 2009. doi: 10.3748/wjg.15.489
Endoscopic features predictive of gastric cancer in superficial lesions with biopsy-proven high grade intraepithelial neoplasia
Wei Wu, Yun-Lin Wu, Yan-Bo Zhu, Qing Wei, Yan Guo, Zheng-Gang Zhu, Yao-Zong Yuan
Wei Wu, Yun-Lin Wu, Yao-Zong Yuan, Department of Gastroenterology, Shanghai Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Yan-Bo Zhu, Qing Wei, Yan Guo, Department of Pathology, Shanghai Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Zheng-Gang Zhu, Department of Surgery, Shanghai Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Author contributions: Yuan YZ designed the study; Wu YL and Zhu ZG coordinated the study; Zhu YB, Wei Q and Guo Y contributed to the pathologic examination; Wu W and Wu YL wrote the paper and analyzed the data.
Correspondence to: Yao-Zong Yuan, Professor, Department of Gastroenterology, Shanghai Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China. yyz28@medmail.com.cn
Telephone: +86-21-64370045
Fax: +86-21-64150773
Received: August 17, 2008
Revised: December 22, 2008
Published online: January 28, 2009
Abstract

AIM: To investigate the macroscopic and clinico-pathologic features of gastric cancer in patients with biopsy-suggested high grade intraepithelial neoplasia.

METHODS: Patients with biopsy-confirmed gastric high grade intraepithelial neoplasia were reviewed from January 2001 to March 2008. Pathologic sections were re-evaluated by two senior pathologists. Patients with an en-bloc resection of the lesion within two months after the diagnosis of high grade intraepithelial neoplasia were enrolled in the study. Clinical manifestations, endoscopic features, biopsy and surgical pathology of all patients were collected and analyzed. The data acquired were subjected to univariate and multivariate analysis.

RESULTS: Seventy-two superficial gastric lesions with a pathologic diagnosis of high grade intraepithelial neoplasia based on biopsy specimens were enrolled. True high grade intraepithelial neoplasia was finally proved in 16 lesions and gastric cancer in the rest 56 lesions, most of which (96.4%) were differentiated carcinomas. The result of univariate analysis indicated that the size and the presence of marked ulcer plaque or scar in a superficial lesion were independently associated with gastric cancer (P < 0.05), when high grade intraepithelial neoplasia was diagnosed by biopsy pathology. The results of multivariate analysis revealed the size greater than 1.5 cm [odds ratio (OR) 18.400, P < 0.001] and the presence of 5-odd mm ulcer plaque or scar (OR 10.000, P = 0.044) were associated with gastric cancer. Accordingly, the sensitivity, specificity and negative predictive value of multivariate analysis for predicting “true high grade intraepithelial neoplasia” was 87.5%, 89.3% and 96.2%, respectively.

CONCLUSION: Macroscopic findings are of value in differentiation between high grade intraepithelial neoplasia and superficial gastric cancer. This may simplify patient work-up and save costs for patients and healthcare system.

Keywords: Stomach neoplasm, Precancerous conditions, Carcinoma in situ, Endoscopy, Gastrointestinal, Path-ology