Tseng CC, Fang WF, Chung YH, Wang YH, Douglas IS, Lin MC. Clinical outcomes in patients with ICU-related pancreatitis. World J Gastroenterol 2009; 15(39): 4938-4944 [PMID: 19842226 DOI: 10.3748/wjg.15.4938]
Corresponding Author of This Article
Dr. Meng-Chih Lin, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, No. 123, Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 83301, Taiwan, China. mengchih@adm.cgmh.org.tw
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Brief Article
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World J Gastroenterol. Oct 21, 2009; 15(39): 4938-4944 Published online Oct 21, 2009. doi: 10.3748/wjg.15.4938
Clinical outcomes in patients with ICU-related pancreatitis
Chia-Cheng Tseng, Wen-Feng Fang, Yu-Hsiu Chung, Yi-Hsi Wang, Ivor S Douglas, Meng-Chih Lin
Chia-Cheng Tseng, Wen-Feng Fang, Yu-Hsiu Chung, Yi-Hsi Wang, Meng-Chih Lin, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien 83301, Taiwan, China
Chia-Cheng Tseng, Wen-Feng Fang, Yu-Hsiu Chung, Yi-Hsi Wang, Meng-Chih Lin, Department of Respiratory Care, Chang Gung Institute of Technology, Chiayi Hsien 61363, Taiwan, China
Ivor S Douglas, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, Denver Health Medical Center, Denver 80204, Colorado
Author contributions: Tseng CC and Fang WF contributed equally to the article; Tseng CC designed the study, collected the data, performed the initial drafting of the manuscript, and the primary data analysis; Fang WF designed the study, collected the data and carried out the final data analysis; Chung YH and Wang YH collected the data; Douglas IS contributed to discussions and revision of the paper and corrected the English grammar; Lin MC designed the study; All authors read, approved, and contributed to the final draft of the manuscript.
Correspondence to: Dr. Meng-Chih Lin, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, No. 123, Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 83301, Taiwan, China. mengchih@adm.cgmh.org.tw
Received: July 17, 2009 Revised: August 24, 2009 Accepted: August 31, 2009 Published online: October 21, 2009
Abstract
AIM: To identify risk factors predictive of intensive care unit (ICU) mortality in patients with ventilator-related pancreatitis. The clinical outcomes of patients with ventilator-related pancreatitis were compared with those of patients with pancreatitis-related respiratory failure as well as controls.
METHODS: One hundred and forty-eight patients with respiratory failure requiring mechanical ventilation and concomitant acute pancreatitis were identified from a prospectively collected dataset of 9108 consecutive patients admitted with respiratory failure over a period of five years. Sixty patients met the criteria for ventilator-related pancreatitis, and 88 (control patients), for pancreatitis-related respiratory failure.
RESULTS: Mortality rate in ventilator-related pancreatitis was comparable to that in ICU patients without pancreatitis by case-control methodology (P = 0.544). Multivariate logistic regression analysis identified low PaO2/FiO2 (OR: 1.032, 95% CI: 1.006-1.059, P = 0.016) as an independent risk factor for mortality in patients with ventilator-related pancreatitis. The mortality rate in patients with ventilator-related pancreatitis was lower than that in patients with acute pancreatitis-related respiratory failure (P < 0.001).
CONCLUSION: We found that low PaO2/FiO2 was an independent clinical parameter predictive of ICU mortality in patients with ventilator-related pancreatitis.
