Clinicopathological significance of LRP16 protein in 336 gastric carcinoma patients

doi:10.3748/wjg.15.4833

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2009; 15(38): 4833-4837
Published online Oct 14, 2009. doi: 10.3748/wjg.15.4833

Clinicopathological significance of LRP16 protein in 336 gastric carcinoma patients

Ya-Zhuo Li, Po Zhao, Wei-Dong Han

Ya-Zhuo Li, Po Zhao, Department of Pathology, Chinese People’s Liberation Army General Hospital, Beijing 100853, China

Wei-Dong Han, Department of Molecular Biology, Institute of Basic Medicine, Chinese People’s Liberation Army General Hospital, Beijing 100853, China

Author contributions: Li YZ performed the majority of experiments and wrote the manuscript; Zhao P designed the study and was also involved in editing the manuscript; Han WD provided some reagents and analytical tools.

Supported by Grant from the Ministry of Science and Technology of China, No. 2010CB912802

Correspondence to: Dr. Po Zhao, Department of Pathology, Chinese People’s Liberation Army General Hospital, Beijing 100853, China. zhaopo@301hospital.com.cn

Telephone: +86-10-66937736 Fax: +86-10-68181689

Received: June 19, 2009
Revised: August 22, 2009
Accepted: August 29, 2009
Published online: October 14, 2009

Abstract

AIM: To investigate the expression of leukemia related protein 16 (LRP16), and the possible relationship between LRP16 expression and clinicopathological indices in 336 gastric carcinoma patients.

METHODS: Immunohistochemistry was used to detect LRP16 expression in 336 cases of paraffin-embedded gastric carcinoma tissues and 60 cases of distal normal mucosa. The relationships between LRP16 expression and patients’ age, tumor size, histological grade, clinical stage, metastatic status and prognosis were analysed.

RESULTS: The expression of LRP16 was 58.6% (197/336) in gastric carcinoma and 31.7% (19/60) in distal normal gastric mucosa. The expression of LRP16 in carcinoma was significantly higher than that in normal mucosa tissues (χ² = 14.929, P = 0.001). LRP16 protein expression was found in 44.1% (63/143) carcinomas at stage I and II, and 69.4% (134/193) carcinomas at stage III and IV (χ² = 21.804, P = 0.001), and in 56.9% (182/320) of cancers without metastasis but 93.8% (15/16) of those with metastasis (χ² = 8.543, P = 0.003). The expression of LRP16 was correlated with tumor size, infiltrative depth, clinical stage, lymphatic invasion and distant metastasis (all P < 0.05). Follow-up data showed that there was a significant difference in median survival time between cancer patients with expression of LRP16 (27.0 mo) and those without (48.0 mo, Log rank =31.644, P = 0.001).

CONCLUSION: The expression of LRP16 may be associated with invasion, metastasis and prognosis of gastric cancer.

Keywords: Gastric neoplasms; Immunohistochemistry; Leukemia related protein 16; Prognosis