Huerta-Franco MR, Vargas-Luna M, Capaccione KM, Yañez-Roldán E, Hernández-Ledezma U, Morales-Mata I, Córdova-Fraga T. Effects of metoclopramide on gastric motility measured by short-term bio-impedance. World J Gastroenterol 2009; 15(38): 4763-4769 [PMID: 19824108 DOI: 10.3748/wjg.15.4763]
Corresponding Author of This Article
María-Raquel Huerta-Franco, MD, PhD, Department of Applied Science and Labor Research, DCS-Campus León, University of Guanajuato, Av. Eugenio Garza Sada 572, Colonia Lomas del Campestre, 37150 León Gto, México. huertafranco@hotmail.com
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World J Gastroenterol. Oct 14, 2009; 15(38): 4763-4769 Published online Oct 14, 2009. doi: 10.3748/wjg.15.4763
Effects of metoclopramide on gastric motility measured by short-term bio-impedance
María-Raquel Huerta-Franco, Miguel Vargas-Luna, Kathleen M Capaccione, Etna Yañez-Roldán, Ulises Hernández-Ledezma, Ismael Morales-Mata, Teodoro Córdova-Fraga
María-Raquel Huerta-Franco, Ismael Morales-Mata, Department of Applied Science and Labor Research, DCS-Campus León, University of Guanajuato, Av. Eugenio Garza Sada 572, Colonia Lomas del Campestre, 37150 León Gto, México
Miguel Vargas-Luna, Etna Yañez-Roldán, Ulises Hernández-Ledezma, Teodoro Córdova-Fraga, Department of Physical Engineering, DCI-Campus León, University of Guanajuato, Lomas del Bosque 103, Lomas del Campestre, 37150 León Gto, México
Kathleen M Capaccione, Robert Wood Johnson Medical School, The University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854-5635, United States
Author contributions: Huerta-Franco MR and Vargas-Luna M designed the study, carried out measurements, data analysis, interpretation and drafting of the manuscript; Capaccione KM performed measurements and drafting of the manuscript; Yañez-Roldán E performed measurements and data analysis; Hernández-Ledezma U contributed to software design; Morales-Mata I contributed to hardware design; Córdova-Fraga T contributed to data analysis and interpretation.
Supported by A grant from CONACYT (J50182), The University of Guanajuato (DINPO 00098-08) and the Dean’s Undergraduate Research Fund from The College of Arts and Science, New York University
Correspondence to: María-Raquel Huerta-Franco, MD, PhD, Department of Applied Science and Labor Research, DCS-Campus León, University of Guanajuato, Av. Eugenio Garza Sada 572, Colonia Lomas del Campestre, 37150 León Gto, México. huertafranco@hotmail.com
Telephone: +52-477-7184721 Fax: +52-477-7184721
Received: June 6, 2009 Revised: August 26, 2009 Accepted: September 1, 2009 Published online: October 14, 2009
Abstract
AIM: To analyze the accuracy of short-term bio-impedance as a means of measuring gastric motility.
METHODS: We evaluated differences in the short-term electrical bio-impedance signal from the gastric region in the following conditions: (1) fasting state, (2) after the administration of metoclopramide (a drug that induces an increase in gastric motility) and (3) after food ingestion in 23 healthy volunteers. We recorded the real component of the electrical impedance signal from the gastric region for 1000 s. We performed a Fast Fourier Transform (FFT) on this data and then compared the signal among the fasting, medicated, and postprandial conditions using the median of the area under the curve, the relative area under the curve and the main peak activity.
RESULTS: The median of the area under the curve of the frequency range in the region between 2-8 cycles per minute (cpm) decreased from 4.7 cpm in the fasting condition to 4.0 cpm in the medicated state (t = 3.32, P = 0.004). This concurred with the decrease seen in the relative area under the FFT curve in the region from 4 to 8 cpm from 38.3% to 26.6% (t = 2.81, P = 0.012) and the increase in area in the region from 2 to 4 cpm from 22.4% to 27.7%, respectively (t = -2.5, P = 0.022). Finally the main peak position also decreased in the region from 2 to 8 cpm. Main peak activity in the fasting state was 4.72 cpm and declined to 3.45 cpm in the medicated state (t = 2.47, P = 0.025). There was a decrease from the fasting state to the postprandial state at 3.02 cpm (t = 4.0, P = 0.0013).
CONCLUSION: Short-term electrical bio-impedance can assess gastric motility changes in individuals experiencing gastric stress by analyzing the area medians and relative areas under the FFT curve.
