Dourmishev LA, Draganov PV. Paraneoplastic dermatological manifestation of gastrointestinal malignancies. World J Gastroenterol 2009; 15(35): 4372-4379 [PMID: 19764087 DOI: 10.3748/wjg.15.4372]
Corresponding Author of This Article
Peter V Draganov, MD, Associate Professor of Medicine, Department of Gastroenterology, Hepatology and Nutrition, University of Florida, 1600 SW Archer Road, Room HD 602, PO Box 100214, Gainesville, FL 32610, United States. dragapv@medicine.ufl.edu
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World J Gastroenterol. Sep 21, 2009; 15(35): 4372-4379 Published online Sep 21, 2009. doi: 10.3748/wjg.15.4372
Paraneoplastic dermatological manifestation of gastrointestinal malignancies
Lyubomir A Dourmishev, Peter V Draganov
Lyubomir A Dourmishev, Department of Dermatology and Venereology, Medical University, 1431 Sofia, Bulgaria
Peter V Draganov, Department of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, Florida 32610, United States
Author contributions: Dourmishev LA and Draganov PV contributed equaly to this work.
Correspondence to: Peter V Draganov, MD, Associate Professor of Medicine, Department of Gastroenterology, Hepatology and Nutrition, University of Florida, 1600 SW Archer Road, Room HD 602, PO Box 100214, Gainesville, FL 32610, United States. dragapv@medicine.ufl.edu
Telephone: +1-352-3922877 Fax: +1-352-3923618
Received: March 5, 2009 Revised: May 12, 2009 Accepted: May 19, 2009 Published online: September 21, 2009
Abstract
Numerous dermatological disorders have been associated with underlining malignancies of the gastrointestinal (GI) tract. Such cutaneous manifestations might have an important diagnostic value if they are the sole expressions of otherwise asymptomatic carcinomas. The recognition of some typical paraneoplastic dermatologic disorders can lead to the prompt diagnosis of the underlying malignancy, timely administration of therapy, and ultimately, better prognosis. In this review we discuss the most common paraneoplastic dermatological syndromes from the perspective of the practicing gastroenterologist. We also outline a comprehensive practical approach for the evaluation for occult malignancy in patients presenting with cutaneous findings potentially associated with GI cancers.
