Joo HJ, Kim GH, Jeon WJ, Chae HB, Park SM, Youn SJ, Choi JW, Sung R. Metachronous bile duct cancer nine years after resection of gallbladder cancer. World J Gastroenterol 2009; 15(27): 3440-3444 [PMID: 19610150 DOI: 10.3748/wjg.15.3440]
Corresponding Author of This Article
Seon Mee Park, MD, Department of Internal Medicine, College of Medicine, Chungbuk National University, Gaeshindong 62, Heungdukgu, Cheongju 361-711, South Korea. smpark@chungbuk.ac.kr
Article-Type of This Article
Case Report
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World J Gastroenterol. Jul 21, 2009; 15(27): 3440-3444 Published online Jul 21, 2009. doi: 10.3748/wjg.15.3440
Metachronous bile duct cancer nine years after resection of gallbladder cancer
Hye Jin Joo, Gi Hyun Kim, Won Joong Jeon, Hee Bok Chae, Seon Mee Park, Sei Jin Youn, Jae Woon Choi, Rohyun Sung
Hye Jin Joo, Gi Hyun Kim, Won Joong Jeon, Hee Bok Chae, Seon Mee Park, Sei Jin Youn, Department of Internal Medicine, College of Medicine, Chungbuk National University, Gaeshindong 62, Heungdukgu, Cheongju 361-711, South Korea
Jae Woon Choi, Department of General Surgery, Chungbuk National University, Gaeshindong 62, Heungdukgu, Cheongju 361-711, South Korea
Rohyun Sung, Department of Pathology, College of Medicine, Chungbuk National University, Gaeshindong 62, Heungdukgu, Cheongju 361-711, South Korea
Author contributions: Joo HJ, Youn SJ and Park SM designed the study; Joo HJ wrote the paper; Kim GH, Jeon WJ and Chae HB were involved in the care of the patient; Park SM supervised and approved the final manuscript; Choi JW was the operator of the patient; Sung R contributed to the work on pathology.
Correspondence to: Seon Mee Park, MD, Department of Internal Medicine, College of Medicine, Chungbuk National University, Gaeshindong 62, Heungdukgu, Cheongju 361-711, South Korea. smpark@chungbuk.ac.kr
Telephone: +82-43-2696019
Fax: +82-43-2733252
Received: April 11, 2009 Revised: May 24, 2009 Accepted: May 31, 2009 Published online: July 21, 2009
Abstract
We report a rare case of a 74-year-old man with metachronous gallbladder cancer and bile duct cancer who underwent curative resection twice, with the operations nine years apart. At the age of 65 years, the patient underwent a cholecystectomy and resection of the liver bed for gallbladder cancer. This was a well-differentiated adenocarcinoma, with negative resection margins (T2N0M0, stage IB). Nine years later, during a follow-up examination, abdominal computed tomography and MRCP showed an enhanced 1.7 cm mass in the hilum that extended to the second branch of the right intrahepatic bile duct. We diagnosed this lesion as a perihilar bile duct cancer, Bismuth type IIIa, and performed bile duct excision, right hepatic lobectomy and Roux-en-Y hepaticojejunostomy. The histological diagnosis was a well-differentiated adenocarcinoma with one regional lymph node metastasis (T1N1M0, stage IIB). Twelve months after the second operation, the patient is well, with no signs of recurrence. This case is compared with 11 other cases of metachronous biliary tract cancer published in the world medical literature.
