Pasquini P, Baiocchini A, Falasca L, Annibali D, Gimbo G, Pace F, Nonno FD. Mucosal Schwann cell “Hamartoma”: A new entity? World J Gastroenterol 2009; 15(18): 2287-2289 [PMID: 19437573 DOI: 10.3748/wjg.15.2287]
Corresponding Author of This Article
Laura Falasca, PhD, Lab of Electron Microscopy, INMI-IRCCS “L. Spallanzani”, via Portuense 292, Rome 00149, Italy. falasca@inmi.it
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Author contributions: Annibali D and Gimbo G provided the patient; Pasquini P, Baiocchini A, and Del Nonno F performed the histological and immunohistochemical analyses; Pace F participated in acquisition of data; Falasca L and Del Nonno F carried out the design of the study; Falasca L, Del Nonno F and Baiocchini A drafted the manuscript.
Correspondence to: Laura Falasca, PhD, Lab of Electron Microscopy, INMI-IRCCS “L. Spallanzani”, via Portuense 292, Rome 00149, Italy. falasca@inmi.it
Telephone: +39-6-55170403
Fax: +39-6-55170430
Received: February 13, 2009 Revised: April 10, 2009 Accepted: April 17, 2009 Published online: May 14, 2009
Abstract
Schwannoma is a well-described, benign nerve sheath tumor of the soft tissue, but is rare in the gastrointestinal tract. Gastrointestinal schwannomas are often incidentally discovered as small polypoid intraluminal lesions. In this report, we describe the clinicopathologic and immunohistochemical features of a distinctive neural mucosal polyp composed of a diffuse cellular proliferation of uniform bland spindled cells in the lamina propria that entraps the colonic crypts. Immunohistochemical analysis revealed strong and diffuse positivity for the S-100 protein. To avoid confusion of these solitary colorectal polyps containing pure spindled Schwann cell proliferation in the lamina propria with neural lesions that have significant association with inherited syndromes, it is better to use the designation “mucosal Schwann hamartoma”.
