Kogure T, Ueno Y, Sekiguchi S, Ishida K, Igarashi T, Wakui Y, Iwasaki T, Shimosegawa T. Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma. World J Gastroenterol 2009; 15(10): 1267-1272 [PMID: 19291830 DOI: 10.3748/wjg.15.1267]
Corresponding Author of This Article
Yoshiyuki Ueno, MD, PhD, Division of Gastroenterology, Graduate School of Medicine, Tohoku University, 1-1 Seiryo, Aoba-ku, Sendai 980-8574, Japan. yueno@mail.tains.tohoku.ac.jp
Article-Type of This Article
Case Report
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Takayuki Kogure, Yoshiyuki Ueno, Yuta Wakui, Takao Iwasaki, Tooru Shimosegawa, Division of Gastroenterology, Graduate School of Medicine, Tohoku University, Sendai 980-8574, Japan
Satoshi Sekiguchi, Division of Advanced Surgical Science and Technology, Graduate School of Medicine, Tohoku University, Sendai 980-8574, Japan
Kazuyuki Ishida, Department of Pathology, Tohoku University Hospital, Sendai 980-8574, Japan
Takehiko Igarashi, Division of Gastroenterology Osaki Citizen Hospital, Furukawa 989-6183, Japan
Author contributions: Kogure T, Ueno Y and Wakui Y participated in writing of the manuscript; Kogure T, Ueno Y, Iwasaki T, Shimosegawa T, Sekiguchi S, Ishida K, and Igarashi T participated in treatment of the patient.
Correspondence to: Yoshiyuki Ueno, MD, PhD, Division of Gastroenterology, Graduate School of Medicine, Tohoku University, 1-1 Seiryo, Aoba-ku, Sendai 980-8574, Japan. yueno@mail.tains.tohoku.ac.jp
Telephone: +81-22-7177171
Fax: +81-22-7177177
Received: September 25, 2008 Revised: November 1, 2008 Accepted: November 8, 2008 Published online: March 14, 2009
Abstract
A liver tumor 35 mm in diameter was found incidentally in a 40-year-old woman who had no history of liver diseases or the use of oral contraceptives. Radiological diagnostics showed the typical findings of liver cell adenoma (LCA). Dynamic computed tomography revealed that the tumor showed a homogenous enhancement in the arterial phase and almost the same enhancement as the surrounding liver parenchyma in the delayed phase. The tumor was found to contain fat on magnetic resonance imaging. A benign fat containing liver tumor was suggested. However, radiological findings altered, which caused us to suspect that a well-differentiated hepatocellular carcinoma (HCC) containing fat was becoming dedifferentiated. Partial hepatectomy was performed and the pathological findings showed the typical findings of LCA. This case was an extremely rare LCA, which had no background of risk for LCA and developed the sequential alteration of the radiological findings to suspect well-differentiated HCC.
