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©2009 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Mar 14, 2009; 15(10): 1168-1177
Published online Mar 14, 2009. doi: 10.3748/wjg.15.1168
Published online Mar 14, 2009. doi: 10.3748/wjg.15.1168
In vitro and in vivo models of acute alcohol exposure
Angela Dolganiuc, Gyongyi Szabo, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605-2324, United States
Author contributions: Dolganiuc A and Szabo G performed the literature search, analyzed the data and wrote the paper.
Correspondence to: Angela Dolganiuc, MD, PhD, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States. angela.dolganiuc@umassmed.edu
Telephone: +1-508-8565955
Fax: +1-508-8564770
Received: December 17, 2008
Revised: January 5, 2009
Accepted: January 12, 2009
Published online: March 14, 2009
Revised: January 5, 2009
Accepted: January 12, 2009
Published online: March 14, 2009
Abstract
Alcohol abuse is a global problem due to the financial burden on society and the healthcare system. While the harmful health effects of chronic alcohol abuse are well established, more recent data suggest that acute alcohol consumption also affects human wellbeing. Thus, there is a need for research models in order to fully understand the effect of acute alcohol abuse on different body systems and organs. The present manuscript summarizes the interdisciplinary advantages and disadvantages of currently available human and non-human models of acute alcohol abuse, and identifies their suitability for biomedical research.
Keywords: Models, Acute alcohol abuse, Human, Non-human, Progress