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World J Gastroenterol. Mar 7, 2008; 14(9): 1406-1410
Published online Mar 7, 2008. doi: 10.3748/wjg.14.1406
Scintigraphic evaluation of gallbladder motor functions in H pylori positive and negative patients in the stomach with dyspepsia
Olga Taskaya Yaylali, Mustafa Yilmaz, Fatma Suna Kiraç, Serkan Degirmencioglu, Metin Akbulut
Olga Taskaya Yaylali, Fatma Suna Kiraç, Department of Nuclear Medicine, Pamukkale University, School of Medicine, Denizli 20100, Turkey
Mustafa Yilmaz, Department of Gastroenterology, Pamukkale University, School of Medicine, Denizli 20100, Turkey
Serkan Degirmencioglu, Department of Internal Medicine, Pamukkale University, School of Medicine, Denizli 20100, Turkey
Metin Akbulut, Department of Pathology, Pamukkale University University, School of Medicine, Denizli 20100, Turkey
Author contributions: Yaylali OT, Yilmaz M and Kiraç FS contributed equally to this work; Yaylali OT and Kiraç FS designed research; Yaylali OT, Yilmaz M, Kiraç FS, Akbulut M and Degirmencioglu S performed research; Yaylali OT and Kiraç FS analysed data and wrote the paper.
Correspondence to: Olga Taskaya Yaylali, Department of Nuclear Medicine, Pamukkale University, School of Medicine, Doktorlar Caddesi No. 42, Denizli 20100, Turkey. olgataskaya@yahoo.com
Telephone: +90-258-2410034
Fax: +90-258-2651792
Received: November 3, 2007
Revised: January 8, 2008
Published online: March 7, 2008
Abstract

AIM: To evaluate the relationship between gallbladder (GB) motor function and H pylori infection in the stomach.

METHODS: All cases (86) underwent the 14C urea breath test (UBT). 14C-UBT was found as positive in 58 and negative in 28 dyspeptic patients. 14C- UBT was accepted as a gold standard test. Clo test and histopathologic examination were compared with the results of 14C-UBT in cases who tolerated upper gastrointestinal endoscopy procedure. Cholescintigraphy with 99mTc-mebrofenin was used to determine the parameters of GB motor function (GB filling and emptying time, half of the emptying time, ejection fraction at 30th and 60th min) in all patients.

RESULTS: We found the sensitivity and specificity as 88% and 86% for Clo test and as 89% and 80% for histologic evaluation, respectively. The parameters of GB function were not significantly different in H pylori positive and negative patients. The GB emptying was normal in both groups. Minimum GB filling time was 30 min in 34 of 86 cases (39.5%), filling was not observed in 2 cases. The GB ultrasonography (USG) results were normal for all cases and bile composition abnormality was not determined.

CONCLUSION: Our study showed that 14C-UBT is highly reliable method to detect the presence of H pylori. The presence of H pylori infection does not directly affect the GB function.

Keywords: H pylori; Dyspepsia; Cholescintigraphy; Gallbladder; 14C-urea breath test