Copyright
©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Nov 14, 2008; 14(42): 6572-6574
Published online Nov 14, 2008. doi: 10.3748/wjg.14.6572
Published online Nov 14, 2008. doi: 10.3748/wjg.14.6572
Albumin liver dialysis as pregnancy-saving procedure in cholestatic liver disease and intractable pruritus
Maud Lemoine, Nathalie Ganne-Carrié, Service d’Hépatologie, Hospital Jean-Verdier, Bondy 93140, France
Aurélie Revaux, Guillaume Ducarme, Michèle Uzan, Service de Gynécologie Obstétrique, Hospital Jean-Verdier, Bondy 93140, France
Claire Francoz, Service d’Hépatologie, Hospital Beaujon, Clichy 92110, France
Sabine Brechignac, Service de Médecine interne, Hospital Avicenne, Bobigny 93000, France
Emmanuel Jacquemin, Service d’Hépatologie pédiatrique, Hôpital Kremlin-Bicêtre, Le Kremlin-Bicêtre 94270, France
Author contributions: Lemoine M and co-authors contributed equally to this work; Lemoine M, Revaux A, Ducarme G, Ganne-Carrié N wrote the manuscript; Francoz C performed the both Albumin Liver dialysis; Brechignac S performed the four plasmaphereses; Ducarme G and Uzan M closely supervised the pregnancy and the fetus; Jacquemin E performed the diagnosis of PFIC3.
Correspondence to: Dr. Maud Lemoine, Service d’Hépatologie, Hospital Jean-Verdier, Avenue du 14 juillet, Bondy 93140, France. maud.lemoine@jvr.aphp.fr
Telephone: +33-14-8026296 Fax: +33-14-8026202
Received: August 11, 2008
Revised: September 22, 2008
Accepted: September 29, 2008
Published online: November 14, 2008
Revised: September 22, 2008
Accepted: September 29, 2008
Published online: November 14, 2008
Abstract
Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare cholestatic liver disease. Such liver disease can get worse by female hormone disorder. Albumin dialysis or Molecular Adsorbent Recirculating System (MARS) has been reported to reverse severe cholestasis-linked pruritus. Here, we report the first use of MARS during a spontaneous pregnancy and its successful outcome in a patient with PFIC3 and intractable pruritus. Albumin dialysis could be considered as a pregnancy-saving procedure in pregnant women with severe cholestasis and refractory pruritus.