Copyright
©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Nov 14, 2008; 14(42): 6531-6535
Published online Nov 14, 2008. doi: 10.3748/wjg.14.6531
Colorectal carcinoma in Lagos and Sagamu, Southwest Nigeria: A histopathological review
Fatimah Biade Abdulkareem, Emmanuel Kunle Abudu, Nicholas Awodele Awolola, Stephen Olafimihan Elesha, Olorunda Rotimi, Olakanmi Raphael Akinde, Ayoola Oluwole Atoyebi, Adedoyin Adekunle Adesanya, Adetola Olubunmi Daramola, Adekumbiola Aina Fehintola Banjo, Charles Chidozie Anunobi
Fatimah Biade Abdulkareem, Stephen Olafimihan Elesha, Olakanmi Raphael Akinde, Adetola Olubunmi Daramola, Adekumbiola Aina Fehintola Banjo, Charles Chidozie Anunobi, Morbid Anatomy Department, College of Medicine University of Lagos, P.M.B 12003, Surulere, Lagos, Nigeria
Emmanuel Kunle Abudu, Department of Morbid Anatomy, Olabisi Onabanjo University Teaching Hospital, P.M.B 2001, Sagamu, Nigeria
Nicholas Awodele Awolola, Department of Morbid Anatomy, Lagos University Teaching Hospital, P.M.B 12003, Surulere, Lagos, Nigeria
Olorunda Rotimi, Department of Histopathology & Molecular Pathology, St. James University Hospital, LS1 3EX, Leeds, United Kingdom.
Ayoola Oluwole Atoyebi, Adedoyin Adekunle Adesanya, General Surgery Unit, Department of Surgery, College of Medicine University of Lagos, P.M.B 12003, Surulere, Lagos, Nigeria
Author contributions: Abdulkareem FB initiated and designed the research; Abdulkareem FB and Abudu EK reviewed the slides; Awolola NA retrieved tissue blocks from the archives; Banjo AAF and Abudu EK provided the data from Sagamu and reviewed some of the slides with Abdulkareem FB; Abdulkareem FB wrote the initial draft; Rotimi O, Elesha SO and Daramola AO critically reviewed the initial draft; Akinde OR and Anunobi CC retrieved blocks and data from the three private laboratories in Lagos; Atoyebi AO and Adesanya AA reviewed the clinical aspect. Elesha SO assisted with research grant.
Supported by University of Lagos Central Research Grant, No. 2007/08
Correspondence to: Dr. Fatimah Biade Abdulkareem, Department of Morbid Anatomy, College of Medicine, University of Lagos, P.M.B. 12003, Surulere, Lagos, Nigeria. biade64@yahoo.co.uk
Telephone: +234-1-8737656 Fax: +234-1-5851432
Received: August 22, 2008
Revised: October 15, 2008
Accepted: October 22, 2008
Published online: November 14, 2008
AIM: To study the frequency, gender and age distribution as well as pathological characteristics of colorectal carcinoma (CRC) in Lagos and Sagamu in SW Nigeria.
METHODS: This is a retrospective pathological review of histologically diagnosed CRC from 5 laboratories in Lagos & Sagamu. The clinical data, such as age, sex and clinical summary were extracted from demographic information. Cases of anal cancer were excluded from this study.
RESULTS: There were 420 cases (237 males and 183 females) of CRC. It peaked in the 60-69 year age group (mean: 50.7; SD: 16.2), M:F ratio 1.3:1 and 23% occurred below 40 years. The majority was well to moderately differentiated adenocarcinoma 321 (76.4%), mucinous carcinoma 45 (10.7%) and signet ring carcinoma 5 (1.2%), and more common in patients under 40 years compared to well differentiated tumors. The recto-sigmoid colon was the most common site (58.6%). About 51% and 34% of cases presented at TNM stages II and III, respectively.
CONCLUSION: CRC is the commonest malignant gastrointestinal (GIT) tumor most commonly located in the recto-sigmoid region. The age and sex prevalence and histopathological features concur with reports from other parts of the world.
