Copyright ©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Oct 21, 2008; 14(39): 5962-5968
Published online Oct 21, 2008. doi: 10.3748/wjg.14.5962
MYC and gastric adenocarcinoma carcinogenesis
Danielle Queiroz Calcagno, Mariana Ferreira Leal, Paulo Pimentel Assumpção, Marília de Arruda Cardoso Smith, Rommel Rodríguez Burbano
Danielle Queiroz Calcagno, Rommel Rodríguez Burbano, Human Cytogenetics Laboratory, Biology Science Institute, Federal University of Pará, Belém PA 66075-900, Brazil
Mariana Ferreira Leal, Marília de Arruda Cardoso Smith, Genetics Division, Department of Morphology and Genetics, Federal University of São Paulo, São Paulo SP 04023-900, Brazil
Paulo Pimentel Assumpção, João de Barros Barreto University Hospital, Federal University of Pará, Belém PA 66073-000, Brazil
Author contributions: Calcagno DQ, Leal MF, Assumpção PP, Smith MAC and Burbano RR contributed equally to this work; the authors wrote the paper based on results of their own experience and recent literature sources (PubMed, ISI Web of Science) on gastric cancer.
Supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, DQC, MACS and RRB) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, MFL)
Correspondence to: Rommel Rodríguez Burbano, Laboratório de Citogenética Humana, Departamento de Biologia, Instituto de Ciências Biológicas, Campus Universitário do Guamá/Universidade Federal do Pará, Av. Augusto Correa 01, Belém, PA 66075-900, Brazil.
Telephone: +55-91-32429254 Fax: +55-91-32111601
Received: April 10, 2008
Revised: June 7, 2008
Accepted: June 14, 2008
Published online: October 21, 2008

MYC is an oncogene involved in cell cycle regulation, cell growth arrest, cell adhesion, metabolism, ribosome biogenesis, protein synthesis, and mitochondrial function. It has been described as a key element of several carcinogenesis processes in humans. Many studies have shown an association between MYC deregulation and gastric cancer. MYC deregulation is also seen in gastric preneoplastic lesions and thus it may have a role in early gastric carcinogenesis. Several studies have suggested that amplification is the main mechanism of MYC deregulation in gastric cancer. In the present review, we focus on the deregulation of the MYC oncogene in gastric adenocarcinoma carcinogenesis, including its association with Helicobacter pylori (H pylori) and clinical applications.

Keywords: MYC, Gastric adenocarcinoma, Gastric preneoplastic lesions, Gastric carcinogenesis, Helicobacter pylori