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Copyright ©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Sep 21, 2008; 14(35): 5432-5435
Published online Sep 21, 2008. doi: 10.3748/wjg.14.5432
Is there a role for Tc-99m (V) DMSA scintigraphy in ischemic colitis?
Maria I Stathaki, Ioannis E Koutroubakis, Sophia I Koukouraki, Elias A Kouroumalis, Nikolaos S Karkavitsas
Maria I Stathaki, Sophia I Koukouraki, Nikolaos S Karkavitsas, Department of Nuclear Medicine, University Hospital of Heraklion, Heraklion 71110, Crete, Greece
Ioannis E Koutroubakis, Elias A Kouroumalis, Department of Gastroenterology, University Hospital of Heraklion, Heraklion 71110, Crete, Greece
Author contributions: Stathaki MI, Koukouraki SI, Karkavitsas NS performed and evaluated the scintigraphic images; Koutroubakis IE, Kouroumalis EA collected all clinical data; Stathaki MI, Koutroubakis IE analyzed the data and wrote the paper.
Correspondence to: Ioannis E Koutroubakis, MD, PhD, Assistant Professor of Medicine, University Hospital Heraklion, Department of Gastroenterology, PO Box 1352, Heraklion 71110, Crete, Greece. ktjohn@her.forthnet.gr
Telephone: +30-28-10392253 Fax: +30-28-10542085
Received: May 14, 2008
Revised: August 26, 2008
Accepted: September 2, 2008
Published online: September 21, 2008

AIM: To evaluate the role of pentavalent Tc-99m dimercaptosuccinic acid [Tc-99m (V) DMSA] in the diagnosis of ischemic colitis.

METHODS: Fourteen patients with endoscopically and histologically confirmed ischemic colitis were included in the study. Tc-99m (V) DMSA scintigraphy was performed within 2 d after colonoscopy. Images were considered positive when an area of increased activity was observed in the region of interest and negative when no abnormal tracer uptake was detected.

RESULTS: In 3 out of the 14 patients, Tc-99m (V) DMSA images showed moderate activity in the bowel. The scintigraphic results corresponded with the endoscopic findings. In the other 11 patients, no abnormal tracer uptake was detected in the abdomen.

CONCLUSION: Besides the limited number of patients, Tc-99m (V) DMSA could not be considered as a useful imaging modality for the evaluation of ischemic colitis.

Keywords: Scintigraphy, Technetium-99m pentavalent dimercaptosuccinic acid, Ischemic colitis, Intestinal ischemia, Diagnosis