Changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer

doi:10.3748/wjg.14.1612

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Mar 14, 2008 (publication date) through May 3, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2008; 14(10): 1612-1616
Published online Mar 14, 2008. doi: 10.3748/wjg.14.1612

Changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer

Lin-Bo Wang, Zhi-Nong Jiang, Miao-Ying Fan, Chao-Yang Xu, Wen-Jun Chen, Jian-Guo Shen

Lin-Bo Wang, Chao-Yang Xu, Wen-Jun Chen, Jian-Guo Shen, Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine, Hangzhou 310016, Zhejiang Province, China

Zhi-Nong Jiang, Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine, Hangzhou 310016, Zhejiang Province, China

Miao-Ying Fan, Department of Ultrasonic Diagnostics, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine, Hangzhou 310016, Zhejiang Province, China

Correspondence to: Dr. Jian-Guo Shen, Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine, Hangzhou 310016, Zhejiang Province, China. drshenjianguo@yahoo.com.cn

Telephone: +86-571-86006912

Fax: +86-571-86044817

Received: September 13, 2007
Revised: December 20, 2007
Published online: March 14, 2008

Abstract

AIM: To investigate the changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer.

METHODS: One hundred and seventy-seven gastric cancer patients with lymph node and/or distal metastasis between 1997 and 2001 were reviewed. Differences in histology of the primary and metastatic gastric cancer were assessed. MMP-2 and nm23-H1 immunoreactivity was compared in 44 patients with tumor infiltration to the serosa layer.

RESULTS: Poorly and moderately differentiated metastatic gastric cancer was found in 88.7% (157/177) and primary gastric cancer in 75.7% (134/177) of the patients. The histological type of metastatic gastric cancer that was not completely in accordance with the preponderant histology of primary gastric cancer was observed in 25 patients (14.1%). MMP-2 immunoreactivity in metastatic gastric cancer was significantly stronger than that in primary gastric cancer, while nm23-H1 immunoreactivity showed no difference in primary and metastatic gastric cancer.

CONCLUSION: Metastatic gastric cancer presents more aggressive histological morphology and higher MMP-2 immunoreactivity than primary gastric cancer. This heterogeneity may elicit a possible mechanism of gastric cancer metastasis.

Keywords: Heterogeneity, Gastric cancer, Nm23-H1, MMP-2, Histological change