Rapid Communication
Copyright ©2007 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Dec 28, 2007; 13(48): 6593-6597
Published online Dec 28, 2007. doi: 10.3748/wjg.v13.i48.6593
Combined treatment of hepatocellular carcinoma with partial splenic embolization and transcatheter hepatic arterial chemoembolization
Jin-Hua Huang, Fei Gao, Yang-Kui Gu, Wen-Quan Li, Lian-Wei Lu
Jin-Hua Huang, Fei Gao, Yang-Kui Gu, Wen-Quan Li, Lian-Wei Lu, Department of Imaging and Interventional Radiology, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong Province, China
Correspondence to: Jin-Hua Huang, Department of Imaging and Interventional Radiology, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong Province, China. hjinh@mail.sysu.edu.cn
Telephone: +86-20-87343272 Fax: +86-20-87343272
Received: August 2, 2007
Revised: October 30, 2007
Accepted: November 6, 2007
Published online: December 28, 2007
Abstract

AIM: To prospectively evaluate the efficacy and safety of partial splenic embolization (PSE) combined with transcatheter hepatic arterial chemoembolization (TACE) in treatment of hepatocellular carcinoma (HCC).

METHODS: Fifty patients suffering from primary HCC associated with hypersplenism caused by cirrhosis were randomly assigned to 2 groups: group A receiving PSE combined with TACE (n = 26) and group B receiving TACE alone (n = 24). Follow-up examinations included calculation of peripheral blood cells (leukcytes, platelets and red blood cells) and treatment-associated complications.

RESULTS: Prior to treatment, there was no significant difference in sex, age, Child-Pugh grade, tumor diameter, mass pathology type and peripheral blood cell counts between the 2 groups. After treatment, leukocyte and platelet counts were significantly higher in group A during the 3-mo follow-up period (P < 0.05), but lower in group B (P < 0.05). Severe complications occurred in 3 patients (11.5%) of group A and in 19 patients (79.2%) of group B (P < 0.05), and there was no significant difference in symptoms of post-embolization syndrome, including abdominal pain, fever, mild nausea and vomiting between the 2 groups (P > 0.05).

CONCLUSION: PSE combined with TACE is more effective and safe than TACE alone for patients with HCC associated with hypersplenism caused by cirrhosis.

Keywords: Hepatocellular carcinoma; Hypersplenism; Cirrhosis; Partial splenic embolization; Transcatheter hepatic arterial chemoembolization