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©2007 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2007; 13(47): 6433-6435
Published online Dec 21, 2007. doi: 10.3748/wjg.v13.i47.6433
Published online Dec 21, 2007. doi: 10.3748/wjg.v13.i47.6433
Complete pathological response following down-staging chemoradiation in locally advanced pancreatic cancer: Challenging the boundaries
AZ Khan, V Pitsinis, SS Mudan, Department of Gastrointestinal Surgery, Royal Marsden Hospital, Fulham Road, London, United Kingdom
Author contributions: All authors contributed equally to the work.
Correspondence to: Aamir Z Khan, FRCS Eng (Gen), Department of Gastrointestinal Surgery, Royal Marsden Hospital, Chelsea, London SW3 6JJ, United Kingdom. aamirzkhan@yahoo.com
Telephone: +44-207-3528171 Fax: +44-207-8082988
Received: September 22, 2006
Revised: September 29, 2007
Accepted: November 11, 2007
Published online: December 21, 2007
Revised: September 29, 2007
Accepted: November 11, 2007
Published online: December 21, 2007
Abstract
Pancreatic cancer is an aggressive malignancy, relatively resistant to chemotherapy and radiotherapy, which usually presents late. Disease specific mortality approaches unity despite advances in adjuvant therapy. We present the first reported case of complete pathological response following neoadjuvant therapy in a locally advanced pancreatic adenocarcinoma.
Keywords: Chemotherapy, Pancreatic cancer, Pathology