Copyright
©2007 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Oct 14, 2007; 13(38): 5151-5153
Published online Oct 14, 2007. doi: 10.3748/wjg.v13.i38.5151
Published online Oct 14, 2007. doi: 10.3748/wjg.v13.i38.5151
Sirolimus-related pulmonary toxicity mimicking 'asthma like' symptoms
GL Gupte, S Mahadevan, SV Beath, Liver Unit, Birmingham Children’s Hospital, Steelhouse Lane, B4 6NH, United Kingdom
JR Clarke, Department of Respiratory Medicine, Birmingham Children’s Hospital, Steelhouse Lane, B4 6NH, United Kingdom
H Alton, Department of Radiology, Birmingham Children’s Hospital, Steelhouse Lane, B4 6NH, United Kingdom
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Girish Gupte, Consultant Paediatric Hepatologist, Birmingham Children’s Hospital, Steelhouse Lane, Birmingham B4 6NH, United Kingdom. girish.gupte@bch.nhs.uk
Telephone: + 44-121-3338267 Fax: + 44-121-3338251
Received: June 12, 2007
Revised: August 1, 2007
Accepted: August 7, 2007
Published online: October 14, 2007
Revised: August 1, 2007
Accepted: August 7, 2007
Published online: October 14, 2007
Abstract
Sirolimus is an immunosuppressant with expanding use in pediatric organ transplantation, dermatology and rheumatology. We report two cases of children who developed asthma like symptoms and were diagnosed with interstitial lung disease, which responded to discontinuation of sirolimus. Pediatricians should be aware about the pulmonary side effects of sirolimus.
Keywords: Sirolimus, Pulmonary toxicity, Interstitial lung disease, Asthma, Small bowel transplantation, Intestinal transplantation, Organ transplantation