Radiotherapy for multiple brain metastases from hepatocellular carcinomas

doi:10.3748/wjg.v13.i33.4520

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Sep 7, 2007 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2007; 13(33): 4520-4522
Published online Sep 7, 2007. doi: 10.3748/wjg.v13.i33.4520

Radiotherapy for multiple brain metastases from hepatocellular carcinomas

Nobuyuki Toshikuni, Kazuhiko Morii, Michinori Yamamoto

Nobuyuki Toshikuni, Department of Internal Medicine, Center for Liver Diseases, Kawasaki Hospital, Kawasaki Medical School, Okayama, Japan Department of Internal Medicine, Himeji Red Cross Hospital, Himeji, Japan

Kazuhiko Morii, Department of Internal Medicine, Himeji Red Cross Hospital, Himeji, Japan

Michinori Yamamoto, Department of Radiology, Himeji Red Cross Hospital, Himeji, Japan

Author contributions: All authors contributed equally to the work.

Correspondence to: Nobuyuki Toshikuni, Department of Internal Medicine, Center for Liver Diseases, Kawasaki Hospital, Kawasaki Medical School, 2-1-80 Nakasange, Okayama 700-8505, Japan. n.toshikuni@gmail.com

Telephone: +81-86-2252111 Fax: +81-86-2328343

Received: April 15, 2007
Revised: June 1, 2007
Accepted: June 9, 2007
Published online: September 7, 2007

Abstract

A 78-year-old man with liver cirrhosis was found to have multiple hepatocellular carcinomas (HCCs) and underwent 3 sessions of transcatheter arterial chemoembolization. Fourteen months after diagnosis, the patient presented with left hemiparesis. Contrast-enhanced magnetic resonance imaging showed multiple metastases with ring-shaped enhancement in the cerebrum and cerebellum. There were no metastases to other organs. The metastatic lesions almost completely disappeared after whole-brain radiotherapy with a total dose of 50 Gy. Neurologic symptoms decreased, and the patient’s quality of life improved. The patient underwent 2 more sessions of transcatheter arterial chemoembolization. Twelve months after the diagnosis of brain metastasis, the patient remains alive. The present case indicates that radiotherapy can improve quality of life and prolong survival in some patients with brain metastases from HCCs.

Keywords: Hepatocellular carcinoma; Brain metastasis; Radiotherapy