Correlation analysis of liver tumor-associated genes with liver regeneration

doi:10.3748/wjg.v13.i24.3323

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Jun 28, 2007 (publication date) through Nov 9, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Liver Cancer

World J Gastroenterol. Jun 28, 2007; 13(24): 3323-3332
Published online Jun 28, 2007. doi: 10.3748/wjg.v13.i24.3323

Correlation analysis of liver tumor-associated genes with liver regeneration

Cun-Shuan Xu, Shou-Bing Zhang, Xiao-Guang Chen, Salman Rahman

Cun-Shuan Xu, College of Life Science, Henan Normal University, Xinxiang 453007, Henan Province, China

Shou-Bing Zhang, Xiao-Guang Chen, Key Laboratory for Cell Differentiation Regulation, Xinxiang 453007, Henan Province, China

Salman Rahman, Laboratory of Thrombosis and Vascular Remodelling, Division of Cardiovascular Medicine, King’s College London School of Medicine, St Thomas’ Hospital, Lambeth Palace Road, London SE1 7EH, United Kingdom

Author contributions: All authors contributed equally to the work.

Supported by the National Basic Research 973 Pre-research Program of China, No. 2006CB708506

Correspondence to: Cun-Shuan Xu, Professor, College of Life Science, Henan Normal University, Xinxiang 453007, Henan Province, China. xucs@x263.net

Telephone: +86-373-3326001 Fax: +86-373-3326524

Received: May 8, 2007
Revised: May 11, 2007
Accepted: May 12, 2007
Published online: June 28, 2007

Abstract

AIM: To study at transcriptional level the similarities and differences of the physiological and biochemical activities between liver tumor (LT) and regenerating liver cells.

METHODS: LT-associated genes and their expression changes in LT were obtained from databases and scientific articles, and their expression profiles in rat liver regeneration (LR) were detected using Rat Genome 230 2.0 array. Subsequently their expression changes in LT and LR were compared and analyzed.

RESULTS: One hundred and twenty one LT-associated genes were found to be LR-associated. Thirty four genes were up-regulated, and 14 genes were down-regulated in both LT and regenerating liver; 20 genes up-regulated in LT were down-regulated in regenerating liver; 21 up-regulated genes and 16 down-regulated genes in LT were up-regulated at some time points and down-regulated at others during LR.

CONCLUSION: Results suggested that apoptosis activity suppressed in LT was still active in regenerating liver, and there are lots of similarities and differences between the LT and regenerating liver at the aspects of cell growth, proliferation, differentiation, migration and angiogenesis.

Keywords: Partial hepatectomy; Rat Genome 230 2.0 Array; Apoptosis; Liver regeneration-associated gene; Liver tumor-associated gene